(R)-(+)-1,2-Epoxy-9-decene (CAS 137310-67-9)

Epoxomicin, also known as (R)-(+)-1,2-Epoxy-9-decene, is a natural product extensively utilized in scientific research due to its versatile applications. This compound is renowned for its potent inhibition of the proteasome, a crucial cellular complex responsible for protein degradation. Through its inhibitory effects, Epoxomicin has played a pivotal role in the exploration of proteasome-related pathways and mechanisms in biochemistry and molecular biology. Its significance in scientific research is primarily attributed to its potent inhibition of the proteasome, which has led to breakthrough discoveries in protein degradation studies. Researchers have utilized Epoxomicin to elucidate the proteasome′s involvement in various diseases, including cancer, neurodegenerative disorders, and viral infections. Moreover, Epoxomicin′s wide-ranging biochemical and physiological effects have been investigated extensively. Studies have revealed that Epoxomicin induces apoptosis in cancer cells, inhibits viral replication, and modulates the immune response. It has also shown promising anti-inflammatory properties, leading to investigations into its potential for treating inflammatory disorders. The mechanism of action of Epoxomicin involves irreversible binding to the active site of the proteasome, effectively inhibiting its activity. This inhibition leads to the accumulation of ubiquitinated proteins, providing valuable insights into the proteasome′s function. Epoxomicin′s high specificity for the proteasome has been instrumental in the identification of new proteasome subunits and regulatory mechanisms. Its use as a research tool has significantly contributed to advancing our understanding of protein degradation processes and their implications in various biological contexts. In summary, Epoxomicin is a natural compound known for its inhibitory effects on the proteasome. Its extensive use in scientific research has unveiled novel insights into protein degradation, disease mechanisms, and therapeutic potential. The compound′s specific mode of action and wide-ranging effects make it an indispensable tool for investigating the intricate workings of the proteasome and its significance in cellular processes.