(-)-Quinpirole hydrochloride is an ergoline small molecule selective agonist of D2-like dopamine receptors. The D2-like class includes the D2DR, D3DR and D4DR (D2, D3, and D4 dopamine receptors), and structural similarity of each of these receptor subtypes limits agonist selectivity to the D2-like receptors as a group. Research of conditions of dopamine deficiency such as schizophrenia and Parkinson's disease is usually directed at the D2-like dopamine receptors, and (-)-Quinpirole has been employed along with other D2-like agonists in perturbing and elucidating the chemical landscape beneath these conditions. (-)-Quinpirole demonstrates a neuroprotective effect against glutamate excitotoxicity through D2 receptor agonism, protecting cells from calcium influx, nitric oxide introduction and peroxynitrile generation, all thought to be mediators of glutamate excitotoxicity. The degeneration of dopaminergic neurons by oxygen free radical species is implicated in the progression of Parkinson's disease, and stimulation of D2 receptors by (-)-Quinpirole demonstrated protection against and scavenging of the harmful radicals - this activity was blocked by both a D2 receptor antagonist and a protein synthesis inhibitor, indicating that stimulation of the D2 receptor signals the dopaminergic cell to produce radical-scavenging proteins for protection.
Munro, L.J., and Kokkinidis, L., Infusion of quinpirole and muscimol into the ventral tegmental area inhibits fear-potentiated startle: implications for the role of dopaminine fear expression. Brain Res. 746, 231-238, (1997) Rosenzweig-Lipson, S., and Barrett, J.E., K-Channel blockers attenuate the presynaptic effects of the D2/D3 agonist quinpirole in monkeys. Pharmacol. Biochem. Behav. 51, 843-848, (1995) Sartania, N., and Strange, P.G., Role of conserved serine residues in the interaction of agonists with D3 dopamine receptors. J. Neurochem. 72, 2621-2624, (1999) Kebabian, et al., Compounds selective for dopamine receptor subtypes. Drug Discov. Today 2, 333-340, (1997) Zaworski, P.G., Efficient functional coupling of the human D3 dopamine receptor to G(o) subtype of G proteins in SH-SY5Y cells. Br. J. Pharmacol. 128, 1181, (1999) Sanger, D.J.D., Evidence for a role for dopamine D3 receptors in the effects of dopamine agonists on operant behaviour in rats. Behav. Pharmacol. 7, 477-482, (1996)
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.