Date published: 2025-10-15

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(−)-Quinpirole hydrochloride (CAS 85798-08-9)

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Alternate Names:
(−)-Quinpirole monohydrochloride
Application:
(−)-Quinpirole hydrochloride is a selective agonist of D2-like dopamine receptors
CAS Number:
85798-08-9
Purity:
≥98%
Molecular Weight:
255.79
Molecular Formula:
C13H21N3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-Quinpirole hydrochloride is widely utilized in neuroscientific research due to its role as a selective D2/D3 dopamine receptor agonist. It is often employed in studies exploring the dopaminergic system′s function, particularly in the context of dopamine production and reception. (−)-Quinpirole hydrochloride is used to investigate behaviors that are thought to correlate with dopaminergic neurotransmission to better understand conditions where this system is dysregulated. This chemical is also used in receptor binding assays to characterize the affinity and number of dopamine receptors in various tissues. Additionally, (−)-Quinpirole hydrochloride is instrumental in experiments that investigate the mechanisms of action of chemicals that influence dopaminergic signaling, as well as in the study of synaptic plasticity.


(−)-Quinpirole hydrochloride (CAS 85798-08-9) References

  1. OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz.  |  Keen, AC., et al. 2022. Commun Biol. 5: 256. PMID: 35322196
  2. The D2-like Dopamine Receptor Agonist Quinpirole Microinjected Into the Ventral Pallidum Dose-Dependently Inhibits the VTA and Induces Place Aversion.  |  Peczely, L., et al. 2022. Int J Neuropsychopharmacol. 25: 590-599. PMID: 35348731
  3. 8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats.  |  Cai, Y., et al. 2022. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 208: 467-477. PMID: 35434766
  4. Differential Alterations in Striatal Direct and Indirect Pathways Mediate Two Autism-like Behaviors in Valproate-Exposed Mice.  |  Di, Y., et al. 2022. J Neurosci. 42: 7833-7847. PMID: 36414013
  5. Rapid presynaptic maturation in naturally regenerating axons of the adult mouse olfactory nerve.  |  Browne, LP., et al. 2022. Cell Rep. 41: 111750. PMID: 36476871
  6. Effect of selective dopamine D3 and D4 receptor agonists on trunk pulmonary artery vascular reactivity from control and monocrotaline-treated rats.  |  de Jesus, L., et al. 2022. J Physiol Pharmacol. 73: PMID: 36515630
  7. Effects of quinpirole in the ventral tegmental area on impulsive behaviour during performance on the five-choice serial reaction time task.  |  Toschi, C., et al. 2023. Exp Brain Res. 241: 539-546. PMID: 36625968
  8. Activation of D1R signaling in the medial prefrontal cortex rescues maternal separation-induced behavioral deficits through restoration of excitatory neurotransmission.  |  Yang, Y., et al. 2023. Behav Brain Res. 441: 114287. PMID: 36627054
  9. The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors.  |  Xu, J. and Pittenger, C. 2023. J Biol Chem. 104583. PMID: 36871761
  10. Striatal Subregion-selective Dysregulated Dopamine Receptor-mediated Intracellular Signaling in a Model of DOPA-responsive Dystonia.  |  Roman, KM., et al. 2023. Neuroscience.. PMID: 36871883
  11. A non-hallucinogenic LSD analog with therapeutic potential for mood disorders.  |  Lewis, V., et al. 2023. Cell Rep. 42: 112203. PMID: 36884348

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-Quinpirole hydrochloride, 10 mg

sc-253339
10 mg
$138.00