Date published: 2025-9-12

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Pyridoxamine Dihydrochloride (CAS 524-36-7)

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Alternate Names:
4-(Aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol dihydrochloride
Application:
Pyridoxamine Dihydrochloride is a hydrochloride salt of one form of vitamin B6
CAS Number:
524-36-7
Purity:
≥98%
Molecular Weight:
241.11
Molecular Formula:
C8H12N2O22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Pyridoxamine Dihydrochloride is a hydrochloride salt of one form of vitamin B6. Pyridoxamine dihydrochloride, a dinucleotide phosphate, serves as an antimicrobial agent with demonstrated toxicity against specific bacteria, including Staphylococcus aureus and Bacillus subtilis. Furthermore, it exhibits inhibitory properties against yeast and fungi growth. The compound′s ability to bind calcium within the body potentially contributes to its observed toxicity, particularly in organisms reliant on this element for essential cellular processes.


Pyridoxamine Dihydrochloride (CAS 524-36-7) References

  1. Chlorination of pyridinium compounds. Possible role of hypochlorite, N-chloramines, and chlorine in the oxidation of pyridinoline cross-links of articular cartilage collagen type II during acute inflammation.  |  Daumer, KM., et al. 2000. J Biol Chem. 275: 34681-92. PMID: 10940296
  2. Vitamin B6-dependent Streptococcus mitior (mitis) isolated from patients with systemic infections.  |  Carey, RB., et al. 1975. J Infect Dis. 131: 722-6. PMID: 1094074
  3. Biosynthesis of vitamin B(6) in yeast: incorporation pattern of glucose.  |  Gupta, RN., et al. 2001. J Am Chem Soc. 123: 11353-9. PMID: 11707109
  4. 2'-hydroxypyridoxol, a biosynthetic precursor of vitamins B(6) and B(1) in yeast.  |  Zeidler, J., et al. 2002. J Am Chem Soc. 124: 4542-3. PMID: 11971684
  5. Determination of water-soluble vitamins by liquid chromatography with a parallel dual-electrode electrochemical detector.  |  Hou, W. and Wang, E. 1990. Talanta. 37: 841-4. PMID: 18965030
  6. Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice.  |  Watson, AM., et al. 2011. Diabetologia. 54: 681-9. PMID: 21161164
  7. The role of vitamin B6 as an antioxidant in the presence of vitamin B2-photogenerated reactive oxygen species. A kinetic and mechanistic study.  |  Natera, J., et al. 2012. Photochem Photobiol Sci. 11: 938-45. PMID: 22231514
  8. Abnormality in expression levels of gluconeogenesis-related genes by high-dose supplementation with pyridoxamine in mice.  |  Thi Viet Do, H., et al. 2012. Int J Vitam Nutr Res. 82: 34-40. PMID: 22811375
  9. A 7-day intravenous toxicity study and neurotoxicity assessment of pyridorin in Sprague-Dawley rats.  |  Sullivan, DW., et al. 2017. Hum Exp Toxicol. 36: 718-726. PMID: 27507076
  10. Effect of UV Irradiation on the Nutritional Quality and Cytotoxicity of Apple Juice.  |  Islam, MS., et al. 2016. J Agric Food Chem. 64: 7812-7822. PMID: 27632812
  11. Determination of Vitamin B3 Vitamer (Nicotinamide) and Vitamin B6 Vitamers in Human Hair Using LC-MS/MS.  |  Sallabi, SM., et al. 2021. Molecules. 26: PMID: 34361640
  12. Viridans streptococcal endocarditis: the role of various species, including pyridoxal-dependent streptococci.  |  Roberts, RB., et al. 1979. Rev Infect Dis. 1: 955-66. PMID: 551516
  13. Effect of pyridoxal on growth of nutritionally variant streptococci and other bacteria on sheep blood agar.  |  Reimer, LG. and Reller, LB. 1983. Diagn Microbiol Infect Dis. 1: 273-5. PMID: 6667606

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Pyridoxamine Dihydrochloride, 1 g

sc-219673B
1 g
$27.00

Pyridoxamine Dihydrochloride, 5 g

sc-219673
5 g
$57.00

Pyridoxamine Dihydrochloride, 25 g

sc-219673A
25 g
$149.00

Pyridoxamine Dihydrochloride, 100 g

sc-219673C
100 g
$475.00