Molecular structure of Pyocyanin, CAS Number: 85-66-5
Pyocyanin (CAS 85-66-5)
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Alternate Names:
Sanasin; Sanazin
Application:
Pyocyanin is an antibiotic accelerator of neutrophil apoptosis
CAS Number:
85-66-5
Purity:
≥98%
Molecular Weight:
210.23
Molecular Formula:
C13H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
P. aeruginosa produces several phenazine toxic metabolites, in which the most predominant is a blue pigment, pyocyanin. It has also been reported to induce apoptosis in human lung epithelial cells and to induce premature cellular senescence in mammalian cells. Pyocyanin undergoes nonenzymatic reduction by NADPH, which produces hydrogen peroxide and depletes intracellular glutathione levels, causing oxidative stress in susceptible cells. Pyocyanin may act to accelerate neutrophil apoptosis in vitro, resulting in resolution of acute inflammation that is beneficial for bacterial survival.
Pyocyanin (CAS 85-66-5) References
- Pyocyanin induces oxidative stress in human endothelial cells and modulates the glutathione redox cycle. | Muller, M. 2002. Free Radic Biol Med. 33: 1527-33. PMID: 12446210
- Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivo. | Allen, L., et al. 2005. J Immunol. 174: 3643-9. PMID: 15749902
- Premature cellular senescence induced by pyocyanin, a redox-active Pseudomonas aeruginosa toxin. | Muller, M. 2006. Free Radic Biol Med. 41: 1670-7. PMID: 17145555
- Pyocyanin production by Pseudomonas aeruginosa confers resistance to ionic silver. | Muller, M. and Merrett, ND. 2014. Antimicrob Agents Chemother. 58: 5492-9. PMID: 25001302
- Fast Selective Detection of Pyocyanin Using Cyclic Voltammetry. | Alatraktchi, FA., et al. 2016. Sensors (Basel). 16: PMID: 27007376
- Pyocyanin Inhibits Chlamydia Infection by Disabling Infectivity of the Elementary Body and Disrupting Intracellular Growth. | Li, JL., et al. 2018. Antimicrob Agents Chemother. 62: PMID: 29610203
- Insight into Pseudomonas aeruginosa pyocyanin production under low-shear modeled microgravity. | Sheet, S., et al. 2019. Bioprocess Biosyst Eng. 42: 267-277. PMID: 30535586
- Anti-inflammatory potential of pyocyanin in LPS-stimulated murine macrophages. | Marreiro de Sales-Neto, J., et al. 2019. Immunopharmacol Immunotoxicol. 41: 102-108. PMID: 30623710
- Evaluation of Pyocyanin induced systemic pathogenicity of Pseudomonas aeruginosa. | Rashid, MI., et al. 2020. Pak J Pharm Sci. 33: 915-922. PMID: 33191213
- Metabolic engineering of E. coli for pyocyanin production. | da Silva, AJ., et al. 2021. Metab Eng. 64: 15-25. PMID: 33454430
- Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction. | Peruzzo, R., et al. 2021. Nat Commun. 12: 2103. PMID: 33833234
- Enhancement of pyocyanin production by subinhibitory concentration of royal jelly in Pseudomonas aeruginosa. | Amly, DA., et al. 2021. F1000Res. 10: 14. PMID: 34540201
- Pyocyanin Modulates Gastrointestinal Transformation and Microbiota. | Peng, W., et al. 2022. J Agric Food Chem. 70: 2722-2732. PMID: 35171599
- Pyocyanin biosynthesis protects Pseudomonas aeruginosa from nonthermal plasma inactivation. | Zhou, H., et al. 2022. Microb Biotechnol. 15: 1910-1921. PMID: 35290715
- Pyocyanin and 1-Hydroxyphenazine Promote Anaerobic Killing of Pseudomonas aeruginosa via Single-Electron Transfer with Ferrous Iron. | Kang, J., et al. 2022. Microbiol Spectr. 10: e0231222. PMID: 36321913
Inhibitor of:
TCIRG1.Activator of:
p47-phox.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pyocyanin, 5 mg | sc-205475 | 5 mg | $120.00 | |||
Pyocyanin, 10 mg | sc-205475A | 10 mg | $300.00 | |||
Pyocyanin, 50 mg | sc-205475B | 50 mg | $1000.00 | |||
Pyocyanin, 100 mg | sc-205475C | 100 mg | $1800.00 |