PSMD7 Antibody (24-KK): sc-100458
- PSMD7 Antibody (24-KK) is a mouse monoclonal mouse IgG1 κ κ provided at 100 µg/ml
- raised against recombinant PSMD7 of human origin
- recommended for detection of PSMD7 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PSMD7 Antibody (24-KK). This work is in progress.
PSMD7 Antibody (24-KK) is a mouse monoclonal IgG1 antibody that detects PSMD7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PSMD7, also known as P40, S12, or MOV34, is a crucial regulatory subunit of the 26S Proteasome, which plays a vital role in the ATP-dependent degradation of ubiquitinated proteins, ensuring cellular homeostasis and protein quality control. PSMD7 is characterized by a proteolytically resistant MPN domain, which is significant as part of a family that includes subunits of the proteasome, COP9-signalosome, and translation initiation factor 3 complexes. This structural feature is essential for PSMD7′s function in recognizing and processing ubiquitinated substrates, thereby influencing various cellular processes, including the cell cycle. Notably, PSMD7 interacts with HIV-1 Vpr, linking PSMD7 to the G2/M phase transition of the mammalian cell cycle, which underscores PSMD7′s importance in both normal cellular function and viral pathogenesis. Anti-PSMD7 antibody (24-KK) is an invaluable tool for researchers studying proteasome activity, protein degradation pathways, and their implications in diseases, including cancer and viral infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSMD7 Antibody (24-KK) References:
- PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma via the mTOR/p70S6K pathway. | Shi, K., et al. 2018. FEBS Open Bio. 8: 533-543. PMID: 29632807
- Deubiquitinase PSMD7 regulates cell fate and is associated with disease progression in breast cancer. | Zhao, Y., et al. 2020. Am J Transl Res. 12: 5433-5448. PMID: 33042429
- Identification of PSMD7 as a prognostic factor correlated with immune infiltration in head and neck squamous cell carcinoma. | Zhang, S., et al. 2021. Biosci Rep. 41: PMID: 33687056
- PSMD7 downregulation suppresses lung cancer progression by regulating the p53 pathway. | Xu, X., et al. 2021. J Cancer. 12: 4945-4957. PMID: 34234864
- Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B. | Wang, J., et al. 2021. Int J Biol Sci. 17: 3331-3342. PMID: 34512150
- Differentially Methylated DNA Regions and Left Ventricular Hypertrophy in African Americans: A HyperGEN Study. | Jones, AC., et al. 2022. Genes (Basel). 13: PMID: 36292585
- Significance of liquid-liquid phase separation (LLPS)-related genes in breast cancer: a multi-omics analysis. | Xie, J., et al. 2023. Aging (Albany NY). 15: 5592-5610. PMID: 37338518
- Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization. | Wang, J., et al. 2024. Cell Signal. 114: 110996. PMID: 38040402
- Deubiquitinase PSMD7 facilitates pancreatic cancer progression through activating Nocth1 pathway via modifying SOX2 degradation. | Luo, C., et al. 2024. Cell Biosci. 14: 35. PMID: 38494478
- Integration of ubiquitination-related genes in predictive signatures for prognosis and immunotherapy response in sarcoma. | Qin, H., et al. 2024. Front Oncol. 14: 1446522. PMID: 39469643
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSMD7 Antibody (24-KK) | sc-100458 | 100 µg/ml | $339.00 |