PSGL-1 Antibody (G-9): sc-365506
- PSGL-1 Antibody (G-9) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 39-64 near the N-terminus of PSGL-1 of human origin
- recommended for detection of PSGL-1 of human origin by WB, IP, IF and ELISA
- See PSGL-1 (KPL1): sc-13535 for PSGL-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PSGL-1 Antibody (G-9). This work is in progress.
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SEE ALSO...
PSGL-1 Antibody (G-9) is a mouse monoclonal IgM antibody that detects PSGL-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PSGL-1, also known as P-Selectin glycoprotein ligand or CD162, plays a crucial role in the immune response by mediating the adhesion of leukocytes to the endothelium during inflammation. This interaction is vital for the recruitment of immune cells to sites of injury or infection, highlighting PSGL-1′s importance in maintaining immune homeostasis. PSGL-1 is primarily located on the tips of microvilli of leukocytes, where PSGL-1′s structure, characterized by a disulfide-linked homodimer and a rich extracellular domain composed of serines, threonines, and prolines, facilitates binding to selectins. Notably, PSGL-1 must undergo specific post-translational modifications, including sialylation and fucosylation, to effectively interact with P-Selectin and E-Selectin, underscoring the complexity of functional regulation. Anti-PSGL-1 antibody (G-9) is an essential tool for researchers studying cell adhesion mechanisms and the dynamics of immune cell trafficking.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PSGL-1 Antibody (G-9) References:
- Role of P-selectin and PSGL-1 in coagulation and thrombosis. | Vandendries, ER., et al. 2004. Thromb Haemost. 92: 459-66. PMID: 15351841
- Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles. | Grover, JR., et al. 2015. J Virol. 89: 454-67. PMID: 25320329
- PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease. | Ramos-Sevillano, E., et al. 2016. PLoS Pathog. 12: e1005500. PMID: 26975045
- Mechanical properties of P-selectin PSGL-1 bonds. | Farzi, B., et al. 2019. Colloids Surf B Biointerfaces. 173: 529-538. PMID: 30342396
- The role of PSGL-1 in pathogenesis of systemic inflammatory response and coagulopathy in endotoxemic mice. | Wang, XL., et al. 2019. Thromb Res. 182: 56-63. PMID: 31450009
- PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity. | He, S., et al. 2020. Viruses. 13: PMID: 33396594
- GALNT4 primes monocytes adhesion and transmigration by regulating O-Glycosylation of PSGL-1 in atherosclerosis. | Ye, Z., et al. 2022. J Mol Cell Cardiol. 165: 54-63. PMID: 34974060
- Identification and optimization of peptide inhibitors to block VISTA/PSGL-1 interaction for cancer immunotherapy. | Niu, X., et al. 2023. Acta Pharm Sin B. 13: 4511-4522. PMID: 37969728
- Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma. | Pereira, JL., et al. 2025. Leukemia. 39: 178-188. PMID: 39455852
- A pair of promising immune checkpoints PSGL-1 and VISTA from immunotolerance to immunotherapy. | Peng, M., et al. 2024. Biomark Res. 12: 151. PMID: 39617949
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSGL-1 Antibody (G-9) | sc-365506 | 200 µg/ml | $322.00 | |||
PSGL-1 (G-9) Neutralizing Peptide | sc-365506 P | 100 µg/0.5 ml | $69.00 |