Molecular structure of PSB 36, CAS Number: 524944-72-7
PSB 36 (CAS 524944-72-7)
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Alternate Names:
1-butyl-8-(3-noradamantyl)-3-(3-hydroxypropyl)xanthine
Application:
PSB 36 is a potent Adenosine A1-R antagonist
CAS Number:
524944-72-7
Purity:
≥98%
Molecular Weight:
386.49
Molecular Formula:
C21H30N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PSB 36 is a potent and selective Adenosine A1-R antagonist. PSB 36 displays binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rat Adenosine A1-R, human Adenosine A2B-H, rat Adenosine A2A-R, rat Adenosine A3-R and human Adenosine A3-H, respectively. This compound demonstrates greater selectivity than DPCPX.
PSB 36 (CAS 524944-72-7) References
- Antinociceptive effects of novel A2B adenosine receptor antagonists. | Abo-Salem, OM., et al. 2004. J Pharmacol Exp Ther. 308: 358-66. PMID: 14563788
- Adenosine receptor subtype-selective antagonists in inflammation and hyperalgesia. | Bilkei-Gorzo, A., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 377: 65-76. PMID: 18188542
- Modulation of insulin release by adenosine A1 receptor agonists and antagonists in INS-1 cells: the possible contribution of 86Rb+ efflux and 45Ca2+ uptake. | Töpfer, M., et al. 2008. Cell Biochem Funct. 26: 833-43. PMID: 18979526
- Molecular mechanisms involved in adenosine-induced endothelial cell barrier enhancement. | Umapathy, NS., et al. 2010. Vascul Pharmacol. 52: 199-206. PMID: 20045081
- Adenosine A(2) receptors modulate tubuloglomerular feedback. | Carlström, M., et al. 2010. Am J Physiol Renal Physiol. 299: F412-7. PMID: 20519378
- Perisynaptic glia discriminate patterns of motor nerve activity and influence plasticity at the neuromuscular junction. | Todd, KJ., et al. 2010. J Neurosci. 30: 11870-82. PMID: 20810906
- Downregulation of A(1) and A(2B) adenosine receptors in human trisomy 21 mesenchymal cells from first-trimester chorionic villi. | Gessi, S., et al. 2012. Biochim Biophys Acta. 1822: 1660-70. PMID: 22867902
- Influence of age, body temperature, GABAA receptor inhibition and caffeine on the Hering-Breuer inflation reflex in unanesthetized rat pups. | Arnal, AV., et al. 2013. Respir Physiol Neurobiol. 186: 73-80. PMID: 23318703
- Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms. | Schiedel, AC., et al. 2013. Purinergic Signal. 9: 351-65. PMID: 23359122
- Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling. | Umapathy, SN., et al. 2013. PLoS One. 8: e59733. PMID: 23613714
- A(1) and A(3) adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes. | Gessi, S., et al. 2013. Pharmacol Res. 76: 157-70. PMID: 23969284
- Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors. | Alnouri, MW., et al. 2015. Purinergic Signal. 11: 389-407. PMID: 26126429
- Adenosine Analogues as Opposite Modulators of the Cisplatin Resistance of Ovarian Cancer Cells. | Bednarska-Szczepaniak, K., et al. 2019. Anticancer Agents Med Chem. 19: 473-486. PMID: 30657045
Inhibitor of:
Adenosine A1-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PSB 36, 10 mg | sc-203672 | 10 mg | $317.00 | |||
| US: Only available in the US | ||||||
PSB 36, 50 mg | sc-203672A | 50 mg | $1254.00 | |||
| US: Only available in the US | ||||||