Protoporphyrin-9 CAS: 553-12-8
MF: C34H34N4O4
MW: 562.66

Protoporphyrin-9 (CAS 553-12-8)

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Alternate Names: Protoporphyrin-9 also known as Ooporphyrin; protoporphyrin IX [MeSH: protoporphyrin IX]; protoporphyrin; Protoporpyrin IX; Porphyrinogen IX; Protoporhyrin IX; Kammerer′s porphyrin; Protoporphyrin-1x; H2ppIX; Kammerer′s prophyrin; Protoporphyrin IX; Spectrum_001300; PP-IX
Application: Protoporphyrin-9 is the key porphyrin precursor to heme sites and chlorophyll in animal and plant cells
CAS Number: 553-12-8
Purity: ≥95%
Molecular Weight: 562.66
Molecular Formula: C34H34N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Protoporphyrin-9 is the key porphyrin in animal and plant cells, presenting a precursor scaffold for heme sites and other metal domains contained in metalloproteins. Iron is introduced to the porphyrin to generate heme, the primary oxygen-binding moiety found in proteins. Protoporphyrin-9 as heme is incorporated into hemoglobin, catalase, peroxidase, and certain cytochrome enzymes. Introduction of magnesium into Protoporphyrin-9 and subsequent transformations generates chlorophyll, the main light energy-gathering pigment in plants necessary for photosynthesis. Protoporphyrin-9 is also demonstrated to activate guanylate cyclase, indicating that cellular levels of Protoporphyrin-9 and heme may serve to regulate guanylate cyclase activity and tissue cyclic GMP levels. λex 402 nm, 409 nm λem 625 nm, 633 nm


1. Granick, S. 1948. J. Biol. Chem. 172: 717-727. PMID: 18901193

2. Sano, S., et al. 1961. J. Biol. Chem. 236: 1173-1180. PMID: 13746277

3. Wolin, M.S., et al. 1982. J. Biol. Chem. 257: 13312-13320. PMID: 6128335

Physical State :
Solubility :
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), chloroform, glacial acetic acid, alcohol containing hydrochloric acid, ether containing glacial acetic acid, hydrochloric acid, dilute alkalies, aniline, and pyridine. Insoluble in disodium salts, and dipotassium salts.
Storage :
Store at -20° C
Boiling Point :
~1122.0° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
flavivirus genomic capping: IC50 = 34.59 µM; HIV-1 protease in 5%DMSO: IC50 = 300 µM; HIV-1 P24: EC5050 = 2.17 µM
Fluoresence :
λex 402 nm, λem 625 nm(bound to HRP); λex 409 nm, λem 633 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 7897
MDL Number :
EC Number :
Beilstein Registry :

Download SDS (MSDS)

Certificate of Analysis

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Protoporphyrin-9 (CAS 553-12-8)  Product Citations

See how others have used Protoporphyrin-9 (CAS 553-12-8). Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 27006498  Burton, MJ.|Kapetanaki, SM.|Chernova, T.|Jamieson, AG.|Dorlet, P.|Santolini, J.|Moody, PC.|Mitcheson, JS.|Davies, NW.|Schmid, R.|Raven, EL.|Storey, NM.| et al. 2016. Proc. Natl. Acad. Sci. U.S.A. 113: 3785-90.

PMID: # 25506911  Jo, H. et al. 2014. PLoS ONE. 9: e115362.

PMID: # 23395777  Jin, ML. et al. 2013. Environ. Toxicol. Pharmacol. 35: 335-46.

PMID: # 23859871  Int. Immunopharmacol. 17: 415-26.

PMID: # 32163836  J. Photochem. Photobiol. B, Biol. 205: 111828.

PMID: # 21645546  Immunol. Lett. 139: 93-101.

PMID: # 20833156  Chem. Biol. Interact. 188: 437-45.

PMID: # 31734545  J. Photochem. Photobiol. B, Biol. 201: 111640.

Citations 1 to 8 of 8 total

When can this material be shipped out (CAS 553-12-8)? It would be shipped to Cambridge, MA.

Asked by: Aubrie
Thank you for your question. Please contact our Customer Care Department for current product availability.
Answered by: Technical Support
Date published: 2019-04-13

Hi, I'm interested in utilizing your product (Protoporphyrin-9) as an exogenous photosensitizer in mice. What is the recommended solvent of Pp-9 among those you mentioned is useful to maintain absorbance value at λmax 633 nm? Thanks, Ahmed

Asked by: Ahmed72
Thank you for your question. We do not have any type of protocol for in vivo use.
Answered by: Technical Support
Date published: 2019-03-11

Hello, If I ordered this today, what is the expected shipping time to Perth, Australia? Thanks, Clare

Asked by: Clare
Thank you for your question. Please contact one of our authorized distributors in Australia to request an accurate lead time for shipping and delivery of this biochemical. A link to search for our authorized distributors is provided here.
Answered by: Technical Support
Date published: 2017-01-27
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