Molecular structure of Protoporphyrin-9, CAS Number: 553-12-8
Protoporphyrin-9 (CAS 553-12-8)
See product citations (11)
Alternate Names:
Protoporphyrin-9 also known as Ooporphyrin; protoporphyrin IX [MeSH: protoporphyrin IX]; protoporphyrin; Protoporpyrin IX; Porphyrinogen IX; Protoporhyrin IX; Kammerer′s porphyrin; Protoporphyrin-1x; H2ppIX; Kammerer′s prophyrin; Protoporphyrin IX; Spectrum_001300; PP-IX
Application:
Protoporphyrin-9 is the key porphyrin precursor to heme sites and chlorophyll in animal and plant cells
CAS Number:
553-12-8
Purity:
≥95%
Molecular Weight:
562.66
Molecular Formula:
C34H34N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Protoporphyrin-9 is the key porphyrin in animal and plant cells, presenting a precursor scaffold for heme sites and other metal domains contained in metalloproteins. Iron is introduced to the porphyrin to generate heme, the primary oxygen-binding moiety found in proteins. Protoporphyrin-9 as heme is incorporated into hemoglobin, catalase, peroxidase, and certain cytochrome enzymes. Introduction of magnesium into Protoporphyrin-9 and subsequent transformations generates chlorophyll, the main light energy-gathering pigment in plants necessary for photosynthesis. Protoporphyrin-9 is also demonstrated to activate guanylate cyclase, indicating that cellular levels of Protoporphyrin-9 and heme may serve to regulate guanylate cyclase activity and tissue cyclic GMP levels. lambdaex 402 nm, 409 nm.lambdaem 625 nm, 633 nm
Protoporphyrin-9 (CAS 553-12-8) References
- The micromeasurement of free erythrocyte protoporphyrin as a means of differentiating alpha thalassemia trait from iron deficiency anemia. | Koenig, HM., et al. 1975. J Pediatr. 86: 539-41. PMID: 1127499
- Studies on the biosynthesis of heme in vitro by avian erythrocytes. | ASHENBRUCKER, H., et al. 1956. Blood. 11: 821-33. PMID: 13355892
- Heme biosynthesis; on the incorporation of iron into protoporphyrin. | NISHIDA, G. and LABBE, RF. 1959. Biochim Biophys Acta. 31: 519-24. PMID: 13628681
- Mitochondrial coproporphyrinogen oxidase and protoporphyrin formation. | SANO, S. and GRANICK, S. 1961. J Biol Chem. 236: 1173-80. PMID: 13746277
- Correlation between macroscopic fluorescence and protoporphyrin IX content in psoriasis and actinic keratosis following application of aminolevulinic acid. | Smits, T., et al. 2005. J Invest Dermatol. 125: 833-9. PMID: 16185285
- Active photosensitizers in butter detected by fluorescence spectroscopy and multivariate curve resolution. | Wold, JP., et al. 2006. J Agric Food Chem. 54: 10197-204. PMID: 17177560
- Protoporphyrin 9 as a precursor of chlorophyll. | GRANICK, S. 1948. J Biol Chem. 172: 717-27. PMID: 18901193
- A study of the inhibition/promotion effects of sodium-copper chlorophyllin (SCC)-mediated mutagenesis in somatic cells of Drosophila. | Pimentel, E., et al. 2011. Mutat Res. 722: 52-5. PMID: 21406245
- In vitro antioxidant capacity and antigenotoxic properties of protoporphyrin and structurally related tetrapyrroles. | Mölzer, C., et al. 2012. Free Radic Res. 46: 1369-77. PMID: 22861140
- Impaired secondary oxidant deactivation capacity and enhanced oxidative stress in serum from alveld affected lambs. | Hegge, AB., et al. 2013. J Photochem Photobiol B. 126: 126-34. PMID: 23954345
- Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway. | Lv, J., et al. 2020. Front Pharmacol. 11: 569368. PMID: 33013408
- Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer. | Biancur, DE., et al. 2021. Cell Metab. 33: 199-210.e8. PMID: 33152323
- Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2. | Gu, C., et al. 2021. Sci Bull (Beijing). 66: 925-936. PMID: 33318880
- Evaluation of the genotoxic potential of protoporphyrin IX and the safety of a protoporphyrin IX-rich algal biomass. | Murbach, TS., et al. 2022. J Appl Toxicol. 42: 1253-1275. PMID: 35104912
- Highly sensitive and quick in ovo sexing of domestic chicken eggs by two-wavelength fluorescence spectroscopy. | Preuße, G., et al. 2023. Anal Bioanal Chem. 415: 603-613. PMID: 36462048
- Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme. | Wolin, MS., et al. 1982. J Biol Chem. 257: 13312-20. PMID: 6128335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Protoporphyrin-9, 250 mg | sc-200327 | 250 mg | $90.00 | |||
Protoporphyrin-9, 500 mg | sc-200327A | 500 mg | $160.00 | |||
Protoporphyrin-9, 1 g | sc-200327B | 1 g | $205.00 | |||
Protoporphyrin-9, 5 g | sc-200327C | 5 g | $1005.00 |