Proteasome Inhibitor VII, Antiprotealide

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Application: Proteasome Inhibitor VII, Antiprotealide is which inactivates the β5-subunit of the human 20S proteasome

Purity: ≥95%

Molecular Weight: 275.7

Molecular Formula: C₁₂H₁₈ClNO₄

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

Proteasome Inhibitor VII, Antiprotealide: sc-222200...

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Proteasome Inhibitor VII, Antiprotealide is a cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the β5-subunit of the human 20S proteasome. The compound has shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A.

References

1. Reddy, Leleti Rajender., et al., 2005. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. Journal of the American Chemical Society. 127(25): 8974-6. PMID: 15969573

Physical State :

Solid

Solubility :

Soluble in DMSO.

Storage :

Store at -80° C

Melting Point :

194.33° C (Predicted)

Boiling Point :

484.69° C at 760 mmHg (Predicted)

Density :

1.31 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.53 (Predicted)

IC50 :

chymotrypsin-like activity of 20S proteasome: IC₅₀ = 27 nM (rabbit ); trypsin-like activity of 20S proteasome: IC₅₀ = 211 nM (rabbit); RPMI8226 cells: IC₅₀ = 220 nM (human)

pK Values :

pK_a: 13.27 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

11173422

SMILES :

CC(C)[[email protected]@H]([[email protected]]12C(=O)O[[email protected]]1([[email protected]](C(=O)N2)CCCl)C)O

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Certificate of Analysis

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