Molecular structure of Proteasome Inhibitor VII, Antiprotealide
Proteasome Inhibitor VII, Antiprotealide
Application:
Proteasome Inhibitor VII, Antiprotealide is which inactivates the β5-subunit of the human 20S proteasome
Purity:
≥95%
Molecular Weight:
275.7
Molecular Formula:
C12H18ClNO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable, Omuralide-Salinosporamide hybrid that irreversibly inactivates the 5-subunit of the human 20S proteasome. Shown to be ~2.5-fold more potent than Omuralide and is expected to exhibit comparable whole cell potency to Salinosporamide A.
Proteasome Inhibitor VII, Antiprotealide References
- An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. | Reddy, LR., et al. 2005. J Am Chem Soc. 127: 8974-6. PMID: 15969573
- Tonicity enhancer binding protein (TonEBP) and hypoxia-inducible factor (HIF) coordinate heat shock protein 70 (Hsp70) expression in hypoxic nucleus pulposus cells: role of Hsp70 in HIF-1α degradation. | Gogate, SS., et al. 2012. J Bone Miner Res. 27: 1106-17. PMID: 22322648
Inhibitor of:
Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Proteasome Inhibitor VII, Antiprotealide, 50 µg | sc-222200 | 50 µg | $399.00 |