Prostaglandin E2 Ethanolamide (CAS 194935-38-1)
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Prostaglandin E2 Ethanolamide is an analog of PGE2 (sc-201225) with improved water solubility and stability that has demonstrated the ability to induce apoptosis in HT29 and HCA7/C29 human colorectal carcinoma (CRC) cell lines. Shown to act as an agonist with all four known EP receptor subtypes (EP1 - EP4), but with an affinity that is significantly less than PGE2. This compound is thought to be biosyntesized via COX-2 from the precursor anandamide (sc-200790; N-arachidonoylethanolamide), the endogenous cannabinoid neurotransmitter. These prostaglandin analogues are integral for structure-activity studies used in the deconvolution of these complex biochemical pathways, and in this case demonstrates unique and applicable biochemical activity.
Prostaglandin E2 Ethanolamide (CAS 194935-38-1) References
- Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide. | Ross, RA., et al. 2002. J Pharmacol Exp Ther. 301: 900-7. PMID: 12023517
- Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry. | Weber, A., et al. 2004. J Lipid Res. 45: 757-63. PMID: 14729864
- Misidentification of prostamides as prostaglandins. | Glass, M., et al. 2005. J Lipid Res. 46: 1364-8. PMID: 15863842
- The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. | Patsos, HA., et al. 2005. Gut. 54: 1741-50. PMID: 16099783
- Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2. | Yang, W., et al. 2005. J Lipid Res. 46: 2745-51. PMID: 16150817
- Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). | Correa, F., et al. 2008. Biochem J. 409: 761-70. PMID: 17961121
- Characterisation of the prostaglandin E2-ethanolamide suppression of tumour necrosis factor-α production in human monocytic cells. | Brown, KL., et al. 2013. Biochim Biophys Acta. 1831: 1098-107. PMID: 23542062
- Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s). | Shelnut, EL., et al. 2015. Tetrahedron Lett. 56: 1411-1415. PMID: 25960577
- Novel COX-2 products of n-3 polyunsaturated fatty acid-ethanolamine-conjugates identified in RAW264.7 macrophages. | de Bus, I., et al. 2019. J Lipid Res. 60: 1829-1840. PMID: 31455615
- Synthesis of prostaglandin E2 ethanolamide from anandamide by cyclooxygenase-2. | Yu, M., et al. 1997. J Biol Chem. 272: 21181-6. PMID: 9261124
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prostaglandin E2 Ethanolamide, 500 µg | sc-222196 | 500 µg | $70.00 | |||
Prostaglandin E2 Ethanolamide, 1 mg | sc-222196A | 1 mg | $127.00 |