pp60v-src Autophosphorylation Site, Tyrosine Kinase Substrate (CAS 81493-98-3)
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pp60v-src Autophosphorylation Site, Tyrosine Kinase Substrate Protein is a tyrosine kinase substrate with the ability to phosphorylate. Residues 2-12 in this peptide correspond to the sequence of the reported site of tyrosine phosphorylation (i.e. aa 412-422) in the Rous sarcoma virus (RSV)-encoded transforming protein pp60v-src. This substrate sequence, RRLIEDNEYTARG, was originally described as an EGFR (epidermal growth factor receptor) substrate in A431 cell extracts (Km=0.3-0.6 mM). In vitro tyrosine phosphorylation of the peptide is stimulated by EGF (epidermal growth factor). The compound has shown an ability to reverse the kinase process much like DTT (1,4-Dithiothreitol)(sc-29089) which has resulted in the increased activity of the insulin receptor/kinase.
pp60v-src Autophosphorylation Site, Tyrosine Kinase Substrate (CAS 81493-98-3) References
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- Analysis of disordered proteins using a simple apparatus for millisecond quench-flow H/D exchange. | Keppel, TR. and Weis, DD. 2013. Anal Chem. 85: 5161-8. PMID: 23586525
- Requirement for receptor-intrinsic tyrosine kinase activities during ligand-induced membrane ruffling of KB cells. Essential sites of src-related growth factor receptor kinases. | Izumi, T., et al. 1988. J Biol Chem. 263: 10386-93. PMID: 2839487
- Characterization of affinity-purified insulin receptor/kinase. Effects of dithiothreitol on receptor/kinase function. | Pike, LJ., et al. 1986. J Biol Chem. 261: 3782-9. PMID: 3005300
- Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. | Pike, LJ., et al. 1982. Proc Natl Acad Sci U S A. 79: 1443-7. PMID: 6175968
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pp60v-src Autophosphorylation Site, Tyrosine Kinase Substrate, 1 mg | sc-201165 | 1 mg | $94.00 |