PMF-1 Antibody (G-9): sc-376269
- PMF-1 Antibody (G-9) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 76-180 mapping within an internal region of PMF-1 of human origin
- recommended for detection of PMF-1 of human origin by WB, IP, IF and ELISA
- m-IgG2a BP-HRP is the preferred secondary detection reagent for PMF-1 Antibody (G-9) for WB applications. This reagent is now offered in a bundle with PMF-1 Antibody (G-9) (see ordering information below).
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PMF-1 Antibody (G-9) is a mouse monoclonal IgG2a antibody that detects PMF-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMF-1, or polyamine-modulated factor 1, is a crucial 205 amino acid protein primarily localized in the nucleus, where PMF-1 plays a significant role in kinetochore formation, a process essential for accurate chromosome segregation during cell division. PMF-1 features a coiled-coil domain that facilitates interaction with the leucine-zipper domain of Nrf2, thereby regulating the transcription of SSAT, an enzyme vital for polyamine catabolism. This regulation influences cellular growth and proliferation, particularly in tissues with high metabolic demands. PMF-1 is a key component of the MIS12 complex, which is indispensable for proper chromosomal alignment and segregation, ensuring genomic stability. Notably, PMF-1 is expressed at elevated levels in skeletal muscle and heart tissues, with moderate expression observed in the liver and kidney, and PMF-1 exists in five isoforms generated through alternative splicing, highlighting functional diversity and regulatory potential in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMF-1 Antibody (G-9) | sc-376269 | 200 µg/ml | $316.00 | |||
PMF-1 Antibody (G-9): m-IgG2a BP-HRP Bundle | sc-546057 | 200 µg Ab; 10 µg BP | $354.00 |