Molecular structure of (±)-J 113397, CAS Number: 217461-40-0
(±)-J 113397 (CAS 217461-40-0)
Alternate Names:
1-[(3R,4R)-1-(cyclooctylmethyl)-3-(hydroxymethyl)piperidin-4-yl]-3-ethylbenzimidazol-2-one
Application:
(±)-J 113397 is a potent and selective NOP/KOR-3 antagonist receptor
CAS Number:
217461-40-0
Purity:
>98%
Molecular Weight:
399.58
Molecular Formula:
C24H37N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Potent and selective NOP antagonist receptor (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Nociceptin/orphanin FQ-induced hyperalgesia inhibitor in the mouse tail-flick test.
(±)-J 113397 (CAS 217461-40-0) References
Kawamoto et al (1999) Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J.Med.Chem. 42 5061. Ozaki et al (2000) In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur.J.Pharmacol. 402 45. Marti et al (2007) The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental Parkinsonism through overinhibition of nigrothalamic pathway. J.Neurosci. 27 1297.Inhibitor of:
KOR-3.Activator of:
KOR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-J 113397, 10 mg | sc-204020 | 10 mg | $249.00 | |||
| US: Only available in the US | ||||||
(±)-J 113397, 50 mg | sc-204020A | 50 mg | $1060.00 | |||
| US: Only available in the US | ||||||