Molecular structure of (±)4-Hydroxydebrisoquin, CAS Number: 59333-79-8
(±)4-Hydroxydebrisoquin (CAS 59333-79-8)
Alternate Names:
Ro 37594
Application:
(±)4-Hydroxydebrisoquin is a major metabolite of debrisoquin
CAS Number:
59333-79-8
Purity:
99%
Molecular Weight:
191.2
Molecular Formula:
C10H13N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)4-Hydroxydebrisoquin is a metabolite of debrisoquin that acts as a potent inhibitor of the cytochrome P450 enzyme CYP2D6. It functions by competitively binding to the active site of the enzyme, thereby preventing the metabolism of certain xenobiotics that are substrates for CYP2D6. At the molecular level, (±)4-Hydroxydebrisoquin exerts its mechanism of action by interfering with the enzymatic conversion of its substrates, ultimately impacting their bioavailability and clearance. (±)4-Hydroxydebrisoquin′s ability to modulate the activity of CYP2D6 may be an important component aimed at understanding the metabolism and pharmacokinetics of xenobiotics that are metabolized by this specific enzyme.
(±)4-Hydroxydebrisoquin (CAS 59333-79-8) References
- Debrisoquine metabolism and genetic predisposition to lung cancer. | Law, MR., et al. 1989. Br J Cancer. 59: 686-7. PMID: 2736200
- The metabolism of [14C]-debrisoquine in man. | Idle, JR., et al. 1979. Br J Clin Pharmacol. 7: 257-66. PMID: 371651
- The assay of fentanyl and its metabolites in plasma of patients using gas chromatography with alkali flame ionisation detection and gas chromatography-mass spectrometry. | Van Rooy, HH., et al. 1981. J Chromatogr. 223: 85-93. PMID: 7251778
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)4-Hydroxydebrisoquin, 10 mg | sc-200729 | 10 mg | $156.00 | |||
(±)4-Hydroxydebrisoquin, 50 mg | sc-200729A | 50 mg | $312.00 |