Date published: 2025-12-26

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(±)11-HDoHE (CAS 87018-59-5)

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Alternate Names:
11-hydroxy Docosahexaenoic Acid
Application:
(±)11-HDoHE is a potential marker of oxidative stress
CAS Number:
87018-59-5
Molecular Weight:
344.5
Molecular Formula:
C22H32O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(±)11-HDoHE, identified by the CAS number 87018-59-5, is a hydroxylated form of docosahexaenoic acid (DHA), which is an essential omega-3 fatty acid primarily sourced from fish and other marine life. This specific derivative is characterized by a hydroxyl group located at the eleventh carbon, with the (±) designation indicating the inclusion of both enantiomers of the molecule. In biochemical research, (±)11-HDoHE is studied for its role as a lipid mediator that can influence cellular signaling pathways linked to various biological processes. This compound interacts with specific cellular receptors and enzymes that are crucial in the regulation of inflammatory mediators. These interactions are key to understanding how (±)11-HDoHE can modulate the production and action of cytokines and other inflammatory markers. Researchers focus on (±)11-HDoHE to explore its potential effects on lipid signaling pathways that control cellular responses to environmental and physiological stimuli. By studying this compound, insights into the molecular mechanisms by which omega-3 fatty acids can influence signaling pathways are gained, enhancing our knowledge of their broader roles in cellular function and signaling. This research helps in understanding the complex interactions within cell membranes and how dietary components can affect cellular activities and processes.


(±)11-HDoHE (CAS 87018-59-5) References

  1. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation.  |  Liu, X., et al. 2013. Anal Biochem. 442: 40-50. PMID: 23850559
  2. The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis.  |  Derogis, PB., et al. 2013. PLoS One. 8: e77561. PMID: 24204871
  3. Elevated levels of pro-inflammatory oxylipins in older subjects are normalized by flaxseed consumption.  |  Caligiuri, SP., et al. 2014. Exp Gerontol. 59: 51-7. PMID: 24747581
  4. Stress during slaughter increases lipid metabolites and decreases oxidative stability of farmed rainbow trout (Oncorhynchus mykiss) during frozen storage.  |  Secci, G., et al. 2016. Food Chem. 190: 5-11. PMID: 26212934
  5. Comprehensive analysis of oxylipins in human plasma using reversed-phase liquid chromatography-triple quadrupole mass spectrometry with heatmap-assisted selection of transitions.  |  Chen, GY. and Zhang, Q. 2019. Anal Bioanal Chem. 411: 367-385. PMID: 30406832
  6. Change of tear lipid mediators in a post-trabeculectomy cohort.  |  Ambaw, YA., et al. 2020. Ocul Surf. 18: 565-574. PMID: 32622916
  7. Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.  |  Chistyakov, DV., et al. 2020. Int J Mol Sci. 21: PMID: 33339154
  8. Regioselectivity of an arachidonate 9S-lipoxygenase from Sphingopyxis macrogoltabida that biosynthesizes 9S,15S- and 11S,17S-dihydroxy fatty acids from C20 and C22 polyunsaturated fatty acids.  |  Kim, SE., et al. 2022. Biochim Biophys Acta Mol Cell Biol Lipids. 1867: 159091. PMID: 34902567
  9. Comparative analysis of fat composition in marrow, serum, and muscle from aging C57BL6 mice.  |  Al Saedi, A., et al. 2022. Mech Ageing Dev. 206: 111690. PMID: 35752298
  10. Production of C20 9S- and C22 11S-hydroxy fatty acids by cells expressing Shewanella hanedai arachidonate 9S-lipoxygenase.  |  Kim, MJ., et al. 2023. Appl Microbiol Biotechnol. 107: 247-260. PMID: 36441205

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(±)11-HDoHE, 25 µg

sc-204610
25 µg
$80.00

(±)11-HDoHE, 50 µg

sc-204610A
50 µg
$154.00