PLIC-2 Antibody (QR-2): sc-100612

PLIC-2 Antibody (QR-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects PLIC-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PLIC-2 antibody (QR-2) is available as the non-conjugated form. PLIC-2, also known as ubiquilin 2, plays a crucial role in cellular protein homeostasis by linking the ubiquitin-proteasome system to various cellular processes, including protein degradation and quality control. PLIC-2 is primarily located in the cytoplasm and is involved in the regulation of protein turnover, which is essential for maintaining cellular function and preventing the accumulation of damaged or misfolded proteins. This is particularly important in the context of neurodegenerative diseases, where the failure of protein degradation pathways can lead to the formation of toxic aggregates. PLIC-2 interacts with proteasomes and E3 ubiquitin ligases, facilitating the targeting of substrates for degradation, thereby ensuring that cellular proteins are properly regulated. Additionally, PLIC-2 has been shown to bind to the ATPase domain of the HSP70-like Stch protein, further highlighting its role in cellular stress responses. The ability of PLIC-2 to modulate protein degradation pathways makes it a significant player in both normal cellular physiology and disease states, particularly in neurodegenerative conditions where protein aggregation is a hallmark.

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PLIC-2 Antibody (QR-2) References:

1. Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane.  |  Wu, AL., et al. 1999. Mol Cell. 4: 619-25. PMID: 10549293
2. A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.  |  Kaye, FJ., et al. 2000. FEBS Lett. 467: 348-55. PMID: 10675567
3. Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2-q21.3.  |  Hanaoka, E., et al. 2000. J Hum Genet. 45: 188-91. PMID: 10807547
4. Assignment of ubiquilin2 (UBQLN2) to human chromosome xp11. 23-->p11.1 by GeneBridge radiation hybrids.  |  Kaye, FJ. and Shows, TB. 2000. Cytogenet Cell Genet. 89: 116-7. PMID: 10894951
5. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome.  |  Kleijnen, MF., et al. 2000. Mol Cell. 6: 409-19. PMID: 10983987
6. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation.  |  Mah, AL., et al. 2000. J Cell Biol. 151: 847-62. PMID: 11076969
7. Identification of a new cellular protein that can interact specifically with DAN.  |  Ozaki, T., et al. 1997. DNA Cell Biol. 16: 985-91. PMID: 9303440

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PLIC-2 Antibody (QR-2) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-PLIC-2 Antibody (QR-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PLIC-2 Antibody (QR-2) Specifications

Alternate Product Name: PLIC-2

Product Clone Name: QR-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 555-625

Epitope Target: PLIC-2

Epitope Species: human

Product Reactivity/Detection: PLIC-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for PLIC-2 Antibody (QR-2): N/A