Date published: 2025-12-14

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PKC ζ Pseudo-substrate inhibitor

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Alternate Names:
SIYRRGARRWRKL; Protein Kinase Cζ/ι; Pseudosubstrate Inhibitor
Application:
PKC ζ Pseudo-substrate inhibitor is a selective inhibitor of PKC ζ
Purity:
≥97% (HPLC)
Molecular Weight:
1718
Molecular Formula:
C76H128N30O16
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The PKC ζ Pseudo-substrate inhibitor serves as a fundamental tool in contemporary molecular research, providing crucial insights into the complex regulatory mechanisms governed by protein kinase C zeta (PKC ζ) within cellular signaling networks. This inhibitor, designed to mimic the substrate-binding region of PKC ζ, competes with endogenous substrates for binding to the enzyme′s catalytic domain, effectively blocking its activity. Through its mechanism of action, the PKC ζ Pseudo-substrate inhibitor enables researchers to selectively modulate PKC ζ-mediated signaling pathways, thereby elucidating its role in various cellular processes such as cell proliferation, differentiation, and apoptosis. Widely utilized in biochemical and cell biology studies, this inhibitor has significantly advanced our understanding of PKC ζ signaling and its implications in diverse physiological and pathological conditions. Moreover, research employing this inhibitor has facilitated the identification of novel PKC ζ substrates and regulatory mechanisms, shedding light on the complex interplay between PKC ζ and other signaling molecules. Continued exploration utilizing the PKC ζ Pseudo-substrate inhibitor promises to uncover further insights into the functional significance of PKC ζ in cellular physiology and pathology.


PKC ζ Pseudo-substrate inhibitor References

  1. Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes.  |  Sajan, MP., et al. 1999. J Biol Chem. 274: 30495-500. PMID: 10521430
  2. Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation.  |  Mouton, V., et al. 2007. Cell Signal. 19: 52-61. PMID: 16829026
  3. Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle.  |  Ratz, PH., et al. 2009. Cell Calcium. 46: 65-72. PMID: 19487023
  4. 6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line.  |  Wang, W., et al. 2012. Int J Biochem Cell Biol. 44: 1987-92. PMID: 22846799
  5. Blue-light induced breakdown of barrier function on human retinal epithelial cells is mediated by PKC-ζ over-activation and oxidative stress.  |  Ozkaya, EK., et al. 2019. Exp Eye Res. 189: 107817. PMID: 31563609
  6. Ghrelin Reduces A-Type Potassium Currents in Dopaminergic Nigral Neurons via the PLC/PKCδ Pathway.  |  Xue, B., et al. 2020. Neurosci Bull. 36: 947-950. PMID: 32388709
  7. PKC-ζ Aggravates Doxorubicin-Induced Cardiotoxicity by Inhibiting Wnt/β-Catenin Signaling.  |  Cao, YJ., et al. 2022. Front Pharmacol. 13: 798436. PMID: 35237161
  8. A Mechanism of Action of Metformin in the Brain: Prevention of Methylglyoxal-Induced Glutamatergic Impairment in Acute Hippocampal Slices.  |  Vizuete, AFK., et al. 2024. Mol Neurobiol. 61: 3223-3239. PMID: 37980327
  9. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport.  |  Standaert, ML., et al. 1997. J Biol Chem. 272: 30075-82. PMID: 9374484
  10. Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis.  |  Laudanna, C., et al. 1998. J Biol Chem. 273: 30306-15. PMID: 9804792

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PKC ζ Pseudo-substrate inhibitor, 0.5 mg

sc-3098
0.5 mg
$95.00

Is this product membrane permeable? Thank you!

Asked by: Jz28sail
Thank you for your question. sc-3098, PKC ζ Pseudo-substrate inhibitor is not membrane permeable. If your protocol requires a membrane permeable PKC ζ Pseudo-substrate inhibitor, we recommend sc-397537, PKC ζ Pseudo-substrate inhibitor, Myristoylated (https://www.scbt.com/scbt/product/pkc-zeta-pseudo-substrate-inhibitor-myristoylated?requestFrom=search)
Answered by: Chemical Support 5
Date published: 2017-04-07
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Rated 5 out of 5 by from GayenGayen, et al. (PubMed ID 19706599) used product sc-3098, PKC Pseudo-substrate, to characterize PKC isoform specificity of PST (pancreastatin) using HepG2 cells. -SCBT Publication Review
Date published: 2015-06-21
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PKC ζ Pseudo-substrate inhibitor is rated 5.0 out of 5 by 1.
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