Date published: 2026-1-31

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PKC θ Pseudo-substrate inhibitor

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Alternate Names:
Protein Kinase Cθ Pseudosubstrate Inhibitor; LHQRRGAIKQAKVHHVKC
Application:
PKC θ Pseudo- substrate Inhibitor is inhibitor for in vitro PKCθ kinase assays
Purity:
≥97% by HPLC
Molecular Weight:
2109.5
Molecular Formula:
C91H157N35O21S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The PKC θ Pseudo-substrate Inhibitor is a pivotal tool in contemporary molecular research, offering insights into the complex regulatory mechanisms governed by protein kinase C theta (PKC θ) within cellular signaling networks. This inhibitor, designed to mimic the substrate-binding region of PKC θ, competes with endogenous substrates for binding to the enzyme′s catalytic domain, effectively blocking its activity. Through its mechanism of action, the PKC θ Pseudo-substrate Inhibitor enables researchers to selectively modulate PKC θ-mediated signaling pathways, thereby elucidating its role in various cellular processes such as T cell activation, differentiation, and cytokine production. Widely utilized in biochemical and cell biology studies, this inhibitor has contributed significantly to advancing our understanding of PKC θ signaling and its implications in immune responses and inflammatory processes. Additionally, research employing this inhibitor has facilitated the identification of novel PKC θ substrates and regulatory mechanisms, shedding light on the complex interplay between PKC θ and other signaling molecules in immune cell function. Continued exploration utilizing the PKC θ Pseudo-substrate Inhibitor holds promise for uncovering further insights into the functional significance of PKC θ in cellular physiology and immunological processes.


PKC θ Pseudo-substrate inhibitor References

  1. A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.  |  Osada, S., et al. 1992. Mol Cell Biol. 12: 3930-8. PMID: 1508194
  2. The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells.  |  Liu, J., et al. 2010. J Tissue Eng Regen Med. 4: 329-39. PMID: 20033927
  3. Propofol induces excessive vasodilation of aortic rings by inhibiting protein kinase Cβ2 and θ in spontaneously hypertensive rats.  |  Wang, Y., et al. 2017. Br J Pharmacol. 174: 1984-2000. PMID: 28369981

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PKC θ Pseudo-substrate inhibitor, 0.5 mg

sc-3097
0.5 mg
$97.00