Date published: 2025-12-19

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PKC ε Translocation inhibitor

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Application:
PKC ε Translocation inhibitor is a selective inhibitor of PKC ε translocation to subcellular sites
Purity:
≥97%
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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The PKC ε Translocation inhibitor is a pivotal tool in contemporary molecular research, elucidating the complex mechanisms underlying protein kinase C epsilon (PKC ε) signaling within cellular contexts. This inhibitor targets the translocation of PKC ε from the cytosol to cellular membranes, a crucial step in its activation and subsequent downstream signaling cascades. By selectively blocking this translocation process, the PKC ε Translocation inhibitor effectively modulates PKC ε-mediated signaling pathways involved in cellular processes such as cell proliferation, differentiation, and survival. Through its mechanism of action, this inhibitor enables researchers to dissect the functional roles of PKC ε in diverse physiological and pathological conditions. Widely utilized in biochemical and cell biology studies, the PKC ε Translocation inhibitor has provided significant insights into the regulatory mechanisms governing PKC ε activity and its implications in various cellular processes. Moreover, research employing this inhibitor has facilitated the identification of novel PKC ε substrates and regulatory mechanisms, shedding light on the complex interplay between PKC ε signaling and other cellular signaling pathways. Continued exploration utilizing the PKC ε Translocation inhibitor promises to uncover further insights into the functional significance of PKC ε in cellular physiology and pathology.


PKC ε Translocation inhibitor References

  1. Role of protein kinase C in arginine vasopressin-stimulated ERK and p70S6 kinase phosphorylation.  |  Ghosh, PM., et al. 2004. J Cell Biochem. 91: 1109-29. PMID: 15048868
  2. PMA- and ANG II-induced PKC regulation of the renal Na+-HCO3- cotransporter (hkNBCe1).  |  Perry, C., et al. 2006. Am J Physiol Renal Physiol. 290: F417-27. PMID: 16159892
  3. Protein kinase Cepsilon interacts with cytochrome c oxidase subunit IV and enhances cytochrome c oxidase activity in neonatal cardiac myocyte preconditioning.  |  Ogbi, M. and Johnson, JA. 2006. Biochem J. 393: 191-9. PMID: 16336199
  4. PKC-epsilon-dependent cytosol-to-membrane translocation of pendrin in rat thyroid PC Cl3 cells.  |  Muscella, A., et al. 2008. J Cell Physiol. 217: 103-12. PMID: 18459119
  5. Role of PKCepsilon in PGF2alpha-stimulated MMP-2 secretion from human ciliary muscle cells.  |  Husain, S. and Crosson, CE. 2008. J Ocul Pharmacol Ther. 24: 268-77. PMID: 18462068
  6. Lipid induced overexpression of NF-kappaB in skeletal muscle cells is linked to insulin resistance.  |  Barma, P., et al. 2009. Biochim Biophys Acta. 1792: 190-200. PMID: 19111928
  7. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.  |  Lau, E., et al. 2012. Cell. 148: 543-55. PMID: 22304920
  8. Genetic inhibition of protein kinase Cε attenuates necrosis in experimental pancreatitis.  |  Liu, Y., et al. 2014. Am J Physiol Gastrointest Liver Physiol. 307: G550-63. PMID: 25035113
  9. Brief low [Mg(2+)]o-induced Ca(2+) spikes inhibit subsequent prolonged exposure-induced excitotoxicity in cultured rat hippocampal neurons.  |  Kim, HJ., et al. 2016. Korean J Physiol Pharmacol. 20: 101-9. PMID: 26807029
  10. Oxidative stress induced by NOX2 contributes to neuropathic pain via plasma membrane translocation of PKCε in rat dorsal root ganglion neurons.  |  Xu, J., et al. 2021. J Neuroinflammation. 18: 106. PMID: 33952299

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

PKC ε Translocation inhibitor, 0.5 mg

sc-3099
0.5 mg
$95.00