Pitavastatin Lactone (CAS 141750-63-2)

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Application: Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase

CAS Number: 141750-63-2

Purity: ≥95%

Molecular Weight: 403.45

Molecular Formula: C₂₅H₂₂FNO₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Pitavastatin Lactone is a major phase 2 metabolite of pitavastatin, an inhibitor of HMG-CoA reductase. Studies have shown that conversion between the acid and lactone forms of pitavastatin occurs in the body and that these two forms differ in substrate activity tow.

References

1. Miners, J.O., et al. 2002. Toxicology 181: 453-456. PMID: 12505351
2. Prueksaritanont, T., et al. 2002. Drug Metab. Dispos. 30: 505-512. PMID: 11950779
3. Benet, L.Z., et al. 2003. Curr. Drug Metab. 4: 393-398. PMID: 14529371
4. Lin, J., et al. 2003. Clin. Pharmacokinet. 42: 59-98. PMID: 12489979
5. Fujino, H., et al. 2004. Xenobiotica. 34: 961-971. PMID: 15801541
6. Yamada, I., et al. 2003. Xenobiotica. 33: 789-803. PMID: 12893526
7. Tian, L., et al. 2008. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 865: 127-132. PMID: 18342583

Appearance :

Powder

Physical State :

Solid

Storage :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

9801294

SMILES :

OC1C[[email protected]](OC(=O)C1)\\C=C\\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1

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Certificate of Analysis

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Pitavastatin Lactone (CAS 141750-63-2) Product Citations

See how others have used Pitavastatin Lactone (CAS 141750-63-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 33341662 Shiozawa, A.|Yamaori, S.|Kamijo, S.|Ohmori, S.| et al. 2020. Drug Metab Pharmacokinet. 36: 100364.

PMID: # 25318994 Hosaka, S. et al. 2015. Drug Metab. Dispos. 43: 27-33.

Citations 1 to 2 of 2 total

Rated 5 out of 5 by HF from Toba Toba, H. et al. (PubMed 20678154) found that Pitavastatin Lactone, an HMG-CoA reductase inhibitor, shows renoprotective effects against diabetic nephropathy mediated in part by inhibition of the renal rennin-angiotensin-aldosterone system, including the suppression of angiotensin-converting enzyme expression and aldosterone production. -SCBT Publication Review

Date published: 2015-05-03

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