Piribedil dihydrochloride is a salt form of Piribedil. Piribedil is a dopamine agonist reported to have selectivity for D3DR (D3 subtype receptors) with moderate to non-significant affinity for D2 and D1 receptors. As an atypical dopamine agonist reported to dose-dependently increase locomotor activity in rats and may be due to an indirect mode of action. Prirbedil is also not reported to cause release or inhibition of tritium-labeled dopamine uptake in synaptosomes obtained from rat nucleus accumbens. Additionally, piribedil is reported to have an in vitro affinity to dopamine D3 receptor subtypes as evidenced by receptor binding autoradiography.
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