Molecular structure of Piribedil dihydrochloride, CAS Number: 78213-63-5
Piribedil dihydrochloride (CAS 78213-63-5)
Alternate Names:
2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Application:
Piribedil dihydrochloride is a useful dopaminergic for biological research purposes
CAS Number:
78213-63-5
Purity:
>99%
Molecular Weight:
334.8
Molecular Formula:
C16H18N4O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Piribedil dihydrochloride is a salt form of Piribedil. Piribedil is a dopamine agonist reported to have selectivity for D3DR (D3 subtype receptors) with moderate to non-significant affinity for D2 and D1 receptors. As an atypical dopamine agonist reported to dose-dependently increase locomotor activity in rats and may be due to an indirect mode of action. Prirbedil is also not reported to cause release or inhibition of tritium-labeled dopamine uptake in synaptosomes obtained from rat nucleus accumbens. Additionally, piribedil is reported to have an in vitro affinity to dopamine D3 receptor subtypes as evidenced by receptor binding autoradiography.
Piribedil dihydrochloride (CAS 78213-63-5) References
- Parkinson's disease: pathological mechanisms and actions of piribedil. | Jenner, P. 1992. J Neurol. 239 Suppl 1: S2-8. PMID: 1634907
- Dopaminergic D2 receptor is a key player in the substantia nigra pars compacta neuronal activation mediated by REM sleep deprivation. | Proença, MB., et al. 2014. Neuropharmacology. 76 Pt A: 118-26. PMID: 24012539
- A comparative study of the locomotor activity effects of apomorphine and the 'atypical dopamine agonists' (piribedil and S3608). | Offermeier, J. and van Rooyen, JM. 1986. Life Sci. 38: 895-903. PMID: 3081774
- In vitro affinity of piribedil for dopamine D3 receptor subtypes, an autoradiographic study. | Cagnotto, A., et al. 1996. Eur J Pharmacol. 313: 63-7. PMID: 8905329
- Dopamine Receptors in the Gastrointestinal Tract | XL Zhang, S Liu, Q Sun, JX Zhu. 2021. Dopamine in the Gut. 53-85.
Activator of:
D3DR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Piribedil dihydrochloride, 10 mg | sc-204198 | 10 mg | $119.00 | |||
| US: Only available in the US | ||||||
Piribedil dihydrochloride, 50 mg | sc-204198A | 50 mg | $495.00 | |||
| US: Only available in the US | ||||||