Piribedil dihydrochloride CAS: 78213-63-5
MF: C16H18N4O2•2HCl
MW: 371.26
A useful dopaminergic for biological research purposes.

Piribedil dihydrochloride (CAS 78213-63-5)

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Alternate Names: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride
Application: Piribedil dihydrochloride is a useful dopaminergic for biological research purposes
CAS Number: 78213-63-5
Purity: >99%
Molecular Weight: 371.26
Molecular Formula: C16H18N4O22HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Piribedil dihydrochloride is a salt form of Piribedil. Piribedil is a dopamine agonist reported to have selectivity for D3DR (D3 subtype receptors) with moderate to non-significant affinity for D2 and D1 receptors. As an atypical dopamine agonist reported to dose-dependently increase locomotor activity in rats and may be due to an indirect mode of action. Prirbedil is also not reported to cause release or inhibition of tritium-labeled dopamine uptake in synaptosomes obtained from rat nucleus accumbens. Additionally, piribedil is reported to have an in vitro affinity to dopamine D3 receptor subtypes as evidenced by receptor binding autoradiography.


References

1. Offermeier, J. and van Rooyen, J.M. 1986. Life Sci. 38: 895-903. PMID: 3081774
2. Jenner, P. 1992. J. Neurol. 239: S2-S8. PMID: 1634907
3. Cagnotto, A., et al. 1996. Eur. J. Pharmacol. 313: 63-67. PMID: 8905329

Physical State :
Solid
Solubility :
Soluble in water (25 mM).
Storage :
Store at room temperature
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Serotonin 2a receptor: EC5050 = 9.86 nM (mouse); MOR: EC5050 = 92.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UV9707200
PubChem CID :
56972173
SMILES :
C1CN(CCN1CC2=CC3=C(C=C2)OCO3)C4=NC=CC=N4.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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