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Piperidin-4-one hydrochloride (CAS 41979-39-9)

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Alternate Names:
4-Piperidone hydrochloride
CAS Number:
41979-39-9
Purity:
≥98%
Molecular Weight:
135.59
Molecular Formula:
C5H9NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Piperidin-4-one hydrochloride (P4OH) is a versatile organic compound extensively employed in various scientific research applications. This white, crystalline solid possesses a molecular weight of 179.63 g/mol and exhibits solubility in water and has a melting point ranging from 145 to 147°C. The utility of Piperidin-4-one hydrochloride spans across organic synthesis, showcasing its applications as a reagent, catalyst, and ligand. It plays a role in the synthesis of peptides and metal complexes. Moreover, Piperidin-4-one hydrochloride finds relevance in pharmaceutical synthesis, contributing to the creation of antibiotics and anti-inflammatory drugs. Beyond its synthetic applications, Piperidin-4-one hydrochloride serves as useful in the study of protein structure, function, and drug mechanisms. Piperidin-4-one hydrochloride has been identified as an inhibitor of specific enzymes, including acetylcholinesterase and phospholipase A2. Its mode of action involves interacting with the active site of these enzymes, effectively hindering the binding of the enzyme′s substrate and impeding catalytic reactions.


Piperidin-4-one hydrochloride (CAS 41979-39-9) References

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  2. Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].  |  Oberdorf, C., et al. 2008. J Med Chem. 51: 6531-7. PMID: 18816044
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  4. 1H and 13C NMR spectral study of some 3,5-bis[(E)-thienylmethylene]piperidin-4-ones.  |  Rajeswari, K. and Pandiarajan, K. 2011. Spectrochim Acta A Mol Biomol Spectrosc. 78: 1110-8. PMID: 21233008
  5. Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.  |  Shao, PP., et al. 2012. J Med Chem. 55: 9847-55. PMID: 23098566
  6. Synthesis, spectral characterization and antimicrobial activity of substituted thiazolyl derivatives of 2-quinolones.  |  Katagi, MS., et al. 2013. Drug Res (Stuttg). 63: 53-9. PMID: 23427049
  7. Bioavailable pyrrolo-benzo-1,4-diazines as Na(v)1.7 sodium channel blockers for the treatment of pain.  |  Yang, SW., et al. 2014. Bioorg Med Chem Lett. 24: 4958-62. PMID: 25288187
  8. Potential antibacterial activity of triazine dendrimer: Synthesis and controllable drug release properties.  |  Vembu, S., et al. 2015. Bioorg Med Chem. 23: 4561-4566. PMID: 26113186
  9. Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors.  |  Huang, T., et al. 2015. Molecules. 20: 16221-34. PMID: 26370948
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Piperidin-4-one hydrochloride, 1 g

sc-301550
1 g
$50.00

Piperidin-4-one hydrochloride, 5 g

sc-301550A
5 g
$165.00

Piperidin-4-one hydrochloride, 8 g

sc-301550B
8 g
$300.00