Molecular structure of PIM-1 Inhibitor 2, CAS Number: 477845-12-8
PIM-1 Inhibitor 2 (CAS 477845-12-8)
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Alternate Names:
4-[3-(4-Chlorophenyl)-2,1-benzisoxa zol-5-yl]-2-pyrimidinamine
Application:
PIM-1 Inhibitor 2 is a potent Pim-1 kinase inhibitor
CAS Number:
477845-12-8
Purity:
>97%
Molecular Weight:
322.75
Molecular Formula:
C17H11CIN4O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM). Pim-1 is a proto-oncogene serine/threonine-protein kinase Pim-1 that is encoded by the human PIM1 gene. PIM-1 inhibitor 2 interacts with G-protein coupled receptors, such as the serotonin receptor, as well as enzymes, such as cyclooxygenase and lipoxygenase. Additionally, it can modulate the activity of various ion channels, such as the potassium and sodium channels. This compound has anti-inflammatory, anti-oxidant, anti-convulsant, anti-depressant, anti-cancer, neuroprotective, cardioprotective, and hepatoprotective activities.
PIM-1 Inhibitor 2 (CAS 477845-12-8) References
- Signaling events involved in interleukin 27 (IL-27)-induced proliferation of human naive CD4+ T cells and B cells. | Charlot-Rabiega, P., et al. 2011. J Biol Chem. 286: 27350-62. PMID: 21669870
- Phosphoproteomic analysis of Salmonella-infected cells identifies key kinase regulators and SopB-dependent host phosphorylation events. | Rogers, LD., et al. 2011. Sci Signal. 4: rs9. PMID: 21934108
- Inhibition of the Pim1 oncogene results in diminished visual function. | Yin, J., et al. 2012. PLoS One. 7: e52177. PMID: 23300608
- PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. | Jin, B., et al. 2014. Aging Cell. 13: 879-89. PMID: 25040935
- HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents. | McMahon, M., et al. 2014. PLoS One. 9: e114055. PMID: 25427220
- Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies. | Paramasivan, P., et al. 2019. Cancer Drug Resist. 2: 490-515. PMID: 35582567
- Mayaro Virus: The State-of-the-Art for Antiviral Drug Development. | Andreolla, AP., et al. 2022. Viruses. 14: PMID: 36016409
Inhibitor of:
Pim-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIM-1 Inhibitor 2, 10 mg | sc-204194 | 10 mg | $135.00 | |||
PIM-1 Inhibitor 2, 50 mg | sc-204194A | 50 mg | $570.00 |