Date published: 2025-10-17

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Phosphatidylethanol

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Alternate Names:
1-Palmitoyl-2-oleoyl-sn-3-phosphoethanol; 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanol
Purity:
98%
Molecular Weight:
702.98
Molecular Formula:
C39H75O8P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phosphatidylethanol is a lipid molecule that plays a role in cell membrane structure and function. It is involved in maintaining the integrity and fluidity of the cell membrane, which is for various cellular processes such as signaling, transport, and cell recognition. Phosphatidylethanol is also a precursor for the synthesis of other important lipid molecules, including phosphatidic acid and diacylglycerol, which are involved in intracellular signaling pathways. Phosphatidylethanol interacts with proteins and other lipids in the cell membrane, contributing to the organization and stability of the membrane. Its presence and distribution within the membrane can also influence the activity of membrane-bound enzymes and receptors, impacting cellular responses to external stimuli. Phosphatidylethanol has been implicated in the regulation of membrane fusion events, which are for processes such as exocytosis and endocytosis. Phosphatidylethanol′s role in cell membrane structure and function makes it a significant in various cellular processes and signaling pathways.


Phosphatidylethanol References

  1. Phosphatidylethanol in blood as a marker of chronic alcohol use: a systematic review and meta-analysis.  |  Viel, G., et al. 2012. Int J Mol Sci. 13: 14788-812. PMID: 23203094
  2. Progress in monitoring alcohol consumption and alcohol abuse by phosphatidylethanol.  |  Schröck, A., et al. 2014. Bioanalysis. 6: 2285-94. PMID: 25383738
  3. Phosphatidylethanol Levels, As a Marker of Alcohol Consumption, Are Associated With Risk of Intracerebral Hemorrhage.  |  Johansson, K., et al. 2020. Stroke. 51: 2148-2152. PMID: 32543974
  4. Blood Phosphatidylethanol Concentrations Following Regular Exposure to an Alcohol-Based Mouthwash.  |  Reisfield, GM., et al. 2021. J Anal Toxicol. 45: 950-956. PMID: 33024993
  5. Quantitative determination of phosphatidylethanol in dried blood spots for monitoring alcohol abstinence.  |  Luginbühl, M., et al. 2021. Nat Protoc. 16: 283-308. PMID: 33288956
  6. Quantitation of phosphatidylethanol in dried blood after volumetric absorptive microsampling.  |  Van Uytfanghe, K., et al. 2021. Talanta. 223: 121694. PMID: 33303146
  7. Measurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood-importance of inhibition of post-sampling formation from ethanol.  |  Beck, O., et al. 2021. Anal Bioanal Chem. 413: 5601-5606. PMID: 33590314
  8. Phosphatidylethanol in whole blood of rhesus monkeys correlates with ethanol consumption.  |  Lopez-Cruzan, M., et al. 2021. Alcohol Clin Exp Res. 45: 689-696. PMID: 33616217
  9. Comparison of automated determination of phosphatidylethanol (PEth) in dried blood spots (DBS) with previous manual processing and testing.  |  Fatch, R., et al. 2022. Alcohol. 98: 51-54. PMID: 34767948
  10. Phosphatidylethanol, ethyl glucuronide and ethanol in blood as complementary biomarkers for alcohol consumption.  |  Neumann, J., et al. 2021. J Mass Spectrom Adv Clin Lab. 22: 3-7. PMID: 34939049
  11. Red blood transfusion as a potential source for false-positive phosphatidylethanol levels.  |  Stotts, MJ., et al. 2022. Transfusion. 62: 506-508. PMID: 35146766
  12. Determination of eight phosphatidylethanol homologues in blood by reversed phase liquid chromatography-tandem mass spectrometry - How to avoid co-elution of phosphatidylethanols and unwanted phospholipids.  |  Maria, MH., et al. 2022. J Chromatogr A. 1684: 463566. PMID: 36306689
  13. Miniature mass spectrometer-based point-of-care assay for measuring phosphatidylethanol in blood.  |  Pandey, S., et al. 2023. Analyst. 148: 1430-1436. PMID: 36892479

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phosphatidylethanol, 10 mg

sc-222166
10 mg
$188.00

Phosphatidylethanol, 50 mg

sc-222166A
50 mg
$622.00

What is the conversion from the SI (uM/L) units to the American standard in ng/ml, please? Thank you Dr D

Asked by: docduck
Thank you for your question. Here is a link to a site that may be useful for you to do your conversions: http://unitslab.com
Answered by: Tech Service
Date published: 2019-12-02
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Rated 5 out of 5 by from Various publications cite the use of PhosphatidylethanolVarious publications cite the use of Phosphatidylethanol as a standard in chromatographic assays for phospholipase D activity in intact cells. -SCBT Publication Review
Date published: 2015-01-02
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Phosphatidylethanol is rated 5.0 out of 5 by 1.
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