Phenserine CAS: 101246-66-6
MF: C20H23N3O2
MW: 337.42
Inhibitor of amyloid precursor protein (APP).

Phenserine (CAS 101246-66-6)

Phenserine | CAS 101246-66-6 is rated 5.0 out of 5 by 1.
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Alternate Names: Posiphen
Application: Phenserine is inhibitor of amyloid precursor protein (APP)
CAS Number: 101246-66-6
Purity: >98%
Molecular Weight: 337.42
Molecular Formula: C20H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Phenserine is a physostigmine analog that inhibits AChE( acetylcholinesterase). Inhibits production of Aβ and amyloid precursor protein (APP). Improves morris water maze performance of scopolamine-treated rats.


References

Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073. Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-b peptide. J.Pharmacol.Exp.Ther. 318 855. Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM), ethanol (25 mM), and water (<2 mg/ml).
Storage :
Store at 4° C
Melting Point :
180.78° C (Predicted)
Boiling Point :
~468.7° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
AChE: IC50 = 21 nM (human); BChE: IC50 = 1.3 µM (human)
pK Values :
pKa: 13.05 (Predicted), pKb: 8.36 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY8586000
PubChem CID :
192706
Merck Index :
14: 7260
MDL Number :
MFCD00672748
SMILES :
C[[email protected]@]12CCN([[email protected]@H]1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C

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Certificate of Analysis

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Phenserine (CAS 101246-66-6)  Product Citations

See how others have used Phenserine (CAS 101246-66-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24687915  Asuni, AA. et al. 2014. Ann. Neurol. 75: 684-99.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Chen et al Chen et al. (PubMed ID 24955574) found that phenserine protected neurons against soman-induced cell death in rats by promoting neuroprotective gene expression and reversing that ofHomer1. -SCBT Publication Review
Date published: 2015-03-28
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