Molecular structure of Phenserine, CAS Number: 101246-66-6
Phenserine (CAS 101246-66-6)
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Alternate Names:
Posiphen
Application:
Phenserine is inhibitor of amyloid precursor protein (APP)
CAS Number:
101246-66-6
Purity:
>98%
Molecular Weight:
337.42
Molecular Formula:
C20H23N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phenserine is a physostigmine analog that inhibits AChE(acetylcholinesterase). Inhibits production of Abeta and amyloid precursor protein (APP). Improves morris water maze performance of scopolamine-treated rats.
Phenserine (CAS 101246-66-6) References
- The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. | Greig, NH., et al. 2000. Acta Neurol Scand Suppl. 176: 74-84. PMID: 11261809
- Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. | Shaw, KT., et al. 2001. Proc Natl Acad Sci U S A. 98: 7605-10. PMID: 11404470
- The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. | Lahiri, DK., et al. 2007. J Pharmacol Exp Ther. 320: 386-96. PMID: 17003227
- Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model. | Ponce-Lopez, T., et al. 2011. Brain Res. 1426: 73-85. PMID: 22036080
- The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. | Mikkilineni, S., et al. 2012. Parkinsons Dis. 2012: 142372. PMID: 22693681
- Synthesis of phenserine analogues and evaluation of their cholinesterase inhibitory activities. | Shinada, M., et al. 2012. Bioorg Med Chem. 20: 4901-14. PMID: 22831800
- Was phenserine a failure or were investigators mislead by methods? | Becker, RE. and Greig, NH. 2012. Curr Alzheimer Res. 9: 1174-81. PMID: 23227991
- Cognitive Impairments Induced by Concussive Mild Traumatic Brain Injury in Mouse Are Ameliorated by Treatment with Phenserine via Multiple Non-Cholinergic and Cholinergic Mechanisms. | Tweedie, D., et al. 2016. PLoS One. 11: e0156493. PMID: 27254111
- Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine. | Hoffer, BJ., et al. 2017. J Biomed Sci. 24: 71. PMID: 28886718
- Computational and Kinetic Studies of Acetylcholine Esterase Inhibition by Phenserine. | Tabrez, S. and Damanhouri, GA. 2019. Curr Pharm Des. 25: 2108-2112. PMID: 31258059
- Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. | Iijima, S., et al. 1993. Psychopharmacology (Berl). 112: 415-20. PMID: 7871051
- Phenserine and ring C hetero-analogues: drug candidates for the treatment of Alzheimer's disease. | Greig, NH., et al. 1995. Med Res Rev. 15: 3-31. PMID: 7898167
- Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor. | Patel, N., et al. 1998. Neuroreport. 9: 171-6. PMID: 9592071
Inhibitor of:
AChE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenserine, 50 mg | sc-204188 | 50 mg | $132.00 |