Phenserine is a physostigmine analog that inhibits AChE( acetylcholinesterase). Inhibits production of Aβ and amyloid precursor protein (APP). Improves morris water maze performance of scopolamine-treated rats.
Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073. Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-b peptide. J.Pharmacol.Exp.Ther. 318 855. Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087.
Soluble in DMSO (10 mM), ethanol (25 mM), and water (<2 mg/ml).
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Chen et alChen et al. (PubMed ID 24955574) found that phenserine protected neurons against soman-induced cell death in rats by promoting neuroprotective gene expression and reversing that ofHomer1. -SCBT Publication Review
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