Phenol Red is a compound widely used in culture media which identifies pH changes from neutral (red) to acidic (yellow) values. Typically a change in color from red to yellow indicates high rates of cellular death when used in tissue cultures. In the culture of breast cancer cells Phenol Red has been observed to act as a weak estrogen. In human MCF-7 cells, phenol red has reduced Roscovitine (sc-24002) mediated cell cycle arrest and apoptosis. Phenol red has also induced oogenesis from cells scraped from the surface of adult ovaries.
1. Berthois, Y., et al. 1986. Proc. Natl. Acad. Sci. U.S.A. 83: 2496-2500. PMID: 3458212 2. Bukovsky, A., et al. 2005. Reprod. Biol. Endocrinol. 3: 17. PMID: 15871747 3. Wesierska-Gadek, J., et al. 2006. J. Cell. Biochem. 98: 1367-1379. PMID: 16741967
Soluble in water (3 mg/ml), ethanol (4 mg/ml), methanol, and alcohol (3 mg/ml). Insoluble in chloroform.
Store at room temperature
~562.8° C at 760 mmHg (Predicted)
~1.5 g/cm3 (Predicted)
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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WesierskaWesierska-Gadek et al. (PubMed ID 16741967) found that Phenol Red reduced roscovitine-mediated cell cylce arrests and apoptosis in human MCF-7 cells. -SCBT Publication Review
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