Phenelfamycin E (CAS 114451-31-9)

Phenelfamycin E, a natural antibiotic belonging to the phenelfamycin family, has garnered significant interest in scientific research due to its unique mechanism of action and potential applications in microbiology and drug discovery. Mechanistically, Phenelfamycin E inhibits bacterial protein synthesis by specifically targeting the peptidyl transferase center of the 50S ribosomal subunit. By binding to the A-site of the ribosome, Phenelfamycin E disrupts peptide bond formation during translation, leading to the inhibition of protein synthesis and bacterial growth. This mechanism distinguishes Phenelfamycin E from other antibiotics and renders it effective against a wide range of gram-positive and gram-negative bacteria, including multidrug-resistant strains. In research, Phenelfamycin E has been instrumental in elucidating the structural and functional properties of the bacterial ribosome, providing insights into the molecular basis of antibacterial activity and bacterial resistance mechanisms. Moreover, Phenelfamycin E has been employed as a tool for studying ribosomal RNA interactions, ribosome assembly, and translation regulation. Additionally, Phenelfamycin E′s structural diversity and synthetic accessibility have positioned it as a lead compound in antibiotic discovery programs targeting bacterial infections and antimicrobial resistance. Ongoing research endeavors continue to explore the potential of Phenelfamycin E and its derivatives, offering promising avenues for combating infectious diseases and addressing the global challenge of antibiotic resistance.