Molecular structure of PG 01, CAS Number: 853138-65-5
PG 01 (CAS 853138-65-5)
Alternate Names:
Phenylglycine-01
Application:
PG 01 is a transmembrane conductance regulator used for research purposes
CAS Number:
853138-65-5
Purity:
≥98%
Molecular Weight:
439.55
Molecular Formula:
C28H29N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator which is reported to correct gating defects of CFTR mutants such as ΔF508 (Ka = 0.3 μM), E193K and G970R (Kd values are 0.22 μM and 0.45 μM respectively).
PG 01 (CAS 853138-65-5) References
- Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. | Pedemonte, N., et al. 2005. Mol Pharmacol. 67: 1797-807. PMID: 15722457
- Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. | Caputo, A., et al. 2009. J Pharmacol Exp Ther. 330: 783-91. PMID: 19491324
- Therapeutic potential of cystic fibrosis transmembrane conductance regulator (CFTR) inhibitors in polycystic kidney disease. | Li, H. and Sheppard, DN. 2009. BioDrugs. 23: 203-16. PMID: 19697963
- Influence of cell background on pharmacological rescue of mutant CFTR. | Pedemonte, N., et al. 2010. Am J Physiol Cell Physiol. 298: C866-74. PMID: 20053923
- The Concise Guide to PHARMACOLOGY 2013/14: ion channels. | Alexander, SP., et al. 2013. Br J Pharmacol. 170: 1607-51. PMID: 24528239
- The Concise Guide to PHARMACOLOGY 2015/16: Other ion channels. | Alexander, SP., et al. 2015. Br J Pharmacol. 172: 5942-55. PMID: 26650442
- Potentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel Hydroxypyrazolines. | Park, J., et al. 2016. PLoS One. 11: e0149131. PMID: 26863533
- THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels. | Alexander, SP., et al. 2017. Br J Pharmacol. 174 Suppl 1: S195-S207. PMID: 29055039
- Chemoselective Cu-catalyzed synthesis of diverse N-arylindole carboxamides, β-oxo amides and N-arylindole-3-carbonitriles using diaryliodonium salts. | Kumar Mehra, M., et al. 2021. Org Biomol Chem. 19: 1109-1114. PMID: 33434249
- Small molecule modulators of cystic fibrosis transmembrane conductance regulator (CFTR): Structure, classification, and mechanisms. | Cao, L., et al. 2024. Eur J Med Chem. 265: 116120. PMID: 38194776
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PG 01, 5 mg | sc-358839 | 5 mg | $500.00 | |||
PG 01, 25 mg | sc-358839A | 25 mg | $750.00 |