Perindopril t-Butylamine Salt is an angiotensin-converting enzyme (ACE) inhibitor. Inhibition of this enzyme prevents the formation of angiotensin II from angiotensin I, which in turn prevents vasoconstriction caused by angiotensin II.
Lees, K.R., et al.: Brit. J. Clin. Pharmacol., 23, 159 (1987), Morgan, T., et al.: J. Cardiovasc. Pharmacol., 10, Supp. 7, S116, (1987)
Soluble in chloroform, methanol, water (≥88 mg/ml), DMSO (>10 mg/ml), and ethanol (50 mM).
Store at 4° C
angiotensin-converting enzyme: IC50 = 1.05 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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JawaidJawaid, T. et al. (PubMed 26317078) performed a comparative study of neuroprotective effect of angiotensin converting enzyme (ACE) inhibitors, such as Perindopril, against scopolamine-induced memory impairments in rats. Compared to other ACE inhibitors Perindopril proved to be more effective in memory retention. -SCBT Publication Review
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