Pepsin A Antibody (8003): sc-80914

Pepsin A Antibody (8003) is a mouse monoclonal IgG1 antibody that detects pepsin A in human samples through enzyme-linked immunosorbent assay (ELISA). Anti-pepsin A antibody (8003) provides reliable detection and quantification in research studies. Pepsin A plays a crucial role in the digestive system as one of the primary proteolytic enzymes secreted by the gastric mucosa, where pepsin A is responsible for breaking down proteins into smaller peptides, facilitating nutrient absorption. This enzyme is synthesized as an inactive precursor, pepsinogen, which is activated in the highly acidic environment of the stomach (pH 1-3) through the action of hydrochloric acid. The ability of pepsin A to cleave peptide bonds, particularly those involving aromatic amino acids, is vital for effective protein digestion, as pepsin A ensures that a wide variety of dietary proteins can be processed. Notably, pepsin A is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase found in vertebrate gastric juice, highlighting pepsin A′s importance in the digestive process. Additionally, pepsin A′s activity can be modulated by specific inhibitors, such as ovUS-1, a uterine serpin, which underscores the regulatory mechanisms that can influence digestive enzyme function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Pepsin A Antibody (8003) References:

1. Gastric antibacterial efficiency is different for pepsin A and C.  |  Schreiber, S., et al. 2006. Arch Microbiol. 184: 335-40. PMID: 16333616
2. Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection.  |  Stovold, R., et al. 2007. Am J Respir Crit Care Med. 175: 1298-303. PMID: 17413126
3. Association between tracheal pepsin, a reliable marker of gastric aspiration, and head of bed elevation among ventilated neonates.  |  Garland, JS., et al. 2014. J Neonatal Perinatal Med. 7: 185-92. PMID: 25318633
4. Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis.  |  Wang, J., et al. 2017. Acta Otolaryngol. 137: 1253-1259. PMID: 28784015
5. Evaluation of the binding mechanism of iodine with trypsin and pepsin: A spectroscopic and molecular docking.  |  Wang, Y., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 230: 118036. PMID: 31931358
6. Salivary pepsin A detection related to gastro-oesophageal reflux episodes in children undergoing impedance probe monitoring.  |  Haddad, HA., et al. 2020. Acta Paediatr. 109: 2374-2379. PMID: 32239539
7. The Controversy of Pepsinogen A/Pepsin A in Detecting Extra-Gastroesophageal Reflux.  |  Rao, YF., et al. 2023. J Voice. 37: 748-756. PMID: 34090740
8. Pepsin A in Tracheal Secretions From Patients Receiving Mechanical Ventilation.  |  Talbert, S., et al. 2021. Am J Crit Care. 30: 443-450. PMID: 34719715
9. A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values.  |  Morellon-Sterling, R., et al. 2022. Int J Biol Macromol. 210: 682-702. PMID: 35508226
10. Binding interactions of Vildagliptin with pepsin: A multi-spectroscopic and in-silico approach and a comparative account with metformin.  |  Verma, P., et al. 2024. Spectrochim Acta A Mol Biomol Spectrosc. 304: 123368. PMID: 37748335

The preferred Pepsin A antibody is Pepsin A Antibody (A-10): sc-271798.