Molecular structure of Penitrem A, CAS Number: 12627-35-9
Penitrem A (CAS 12627-35-9)
See product citations (5)
Alternate Names:
Tremortin A; NSC 354845
Application:
Penitrem A is a selective and irreversible blocker of the smooth muscle high conductance Ca2+-activated K+ channel
CAS Number:
12627-35-9
Purity:
≥96%
Molecular Weight:
634.2
Molecular Formula:
C37H44ClNO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Penitrem A, a potent neurotoxin produced by, but not necessarily derived from, several species in the genus Penicillium, displays a capacity to have numerous effects on ion channels and neurotransmitter release. This compound has also been reported to inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. Additionally, Penitrem A shows the ability to induce an increase in the voltage and frequency of electrical activity recorded from the cerebral cortex. Penitrem A is an inhibitor of MaxiKalpha.
Penitrem A (CAS 12627-35-9) References
- Penitrem A and Roquefortine Production by Penicillium commune. | Wagener, RE., et al. 1980. Appl Environ Microbiol. 39: 882-7. PMID: 16345552
- Using roquefortine C as a biomarker for penitrem A intoxication. | Tiwary, AK., et al. 2009. J Vet Diagn Invest. 21: 237-9. PMID: 19286504
- In vitro and in vivo hepatic metabolism of the fungal neurotoxin penitrem A. | Moldes-Anaya, A., et al. 2009. Drug Chem Toxicol. 32: 26-37. PMID: 19514936
- Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function. | Asano, S., et al. 2012. J Pharmacol Exp Ther. 342: 453-60. PMID: 22580348
- Neurotoxicity of Penicillium crustosum secondary metabolites: tremorgenic activity of orally administered penitrem A and thomitrem A and E in mice. | Moldes-Anaya, A., et al. 2012. Toxicon. 60: 1428-35. PMID: 23085423
- The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations. | Berntsen, HF., et al. 2017. Toxicology. 392: 64-70. PMID: 29037868
- In Vitro Toxicokinetics and Phase I Biotransformation of the Mycotoxin Penitrem A in Dogs. | Uhlig, S., et al. 2020. Toxins (Basel). 12: PMID: 32375391
- Production of penitrem A by Penicillium crustosum isolated from foodstuffs. | el-Banna, AA. and Leistner, L. 1988. Int J Food Microbiol. 7: 9-17. PMID: 3275314
- Olive Oil Lignan (+)-Acetoxypinoresinol Peripheral Motor and Neuronal Protection against the Tremorgenic Mycotoxin Penitrem A Toxicity via STAT1 Pathway. | Qusa, MH., et al. 2020. ACS Chem Neurosci. 11: 3575-3589. PMID: 32991800
- Intoxication by tremorgenic mycotoxin (penitrem A) in a dog. | Hocking, AD., et al. 1988. Aust Vet J. 65: 82-5. PMID: 3401148
- Effects of prolonged tremor due to penitrem A in mice. | Jortner, BS., et al. 1986. Drug Chem Toxicol. 9: 101-16. PMID: 3757822
- Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. | Knaus, HG., et al. 1994. Biochemistry. 33: 5819-28. PMID: 7514038
- Brain neurotoxicity of Penitrem A: electrophysiological, behavioral and histopathological study. | Breton, P., et al. 1998. Toxicon. 36: 645-55. PMID: 9643478
Inhibitor of:
MaxiK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Penitrem A, 1 mg | sc-200997 | 1 mg | $77.00 | |||
Penitrem A, 5 mg | sc-200997A | 5 mg | $216.00 |