Molecular structure of PDGFR Tyrosine Kinase Inhibitor I
PDGFR Tyrosine Kinase Inhibitor I
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Application:
PDGFR Tyrosine Kinase Inhibitor I is a cell-permeable and selective, ATP-competitive inhibitor of PDGFR tyrosine kinase
Molecular Weight:
276.3
Molecular Formula:
C17H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A cell-permeable bis (1H-2-indolyl)-1-methanone compound that acts as a selective, ATP-competitive inhibitor of platelet-derived growth factor (PDGF) receptor tyrosine kinase in Swiss 3T3 cells for PDGFR, in vitro and in PAE cells for PDGFβ-R. Potently inhibits Flt3 (Fms-like tyrosine kinase 3) activity. Displays weak activity towards Cdk2/cyclin E, EGFR, ErbB2, FGFR-1, GRK2, JAK-2, PKB/Akt, PKCα,ε,ι, and c-Src kinases. Sensitizes 32D cells to radiation-induced apoptosis. Inhibits DNA synthesis in stimulated-Swiss 3T3 cells (≤ 30 µM), and proliferation of TEL-Flt3-transfected BA/F3 cells.
Inhibitor of:
Flt-3/Flk-2, and PDGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDGFR Tyrosine Kinase Inhibitor I, 1 mg | sc-222142 | 1 mg | $190.00 |