Molecular structure of PD 145305, CAS Number: 90536-15-5
PD 145305 (CAS 90536-15-5)
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Alternate Names:
benzylmercaptoacetic acid; 3-phenyl-2-sulfanylpropanoic acid
Application:
PD 145305 is a useful negative control for the calpain inhibitors
CAS Number:
90536-15-5
Molecular Weight:
182.24
Molecular Formula:
C9H10O2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 145305 is an organic compound which serves as a versatile reagent in various chemical syntheses. Notably, it is employed in the synthesis of flavoring agents and preservatives in food products and plays a role in the manufacture of fragrances and dyes. The compound is known for its ability to engage in chemical reactions such as esterification and acylation due to the reactivity of its carboxylic acid group. In has been researched in the context of antibacterial properties in certain scenarios and has been utilized as an insecticide. Additionally, its capacity to potentially function as an antioxidant is an area of research interest, although this attribute warrants further investigation.
PD 145305 (CAS 90536-15-5) References
- Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway. | Bao, JJ., et al. 2002. Cancer Res. 62: 7264-72. PMID: 12499268
- Inhibition of the cdk5/MEF2 pathway is involved in the antiapoptotic properties of calpain inhibitors in cerebellar neurons. | Verdaguer, E., et al. 2005. Br J Pharmacol. 145: 1103-11. PMID: 15912127
- Calpain-mediated regulation of the distinct signaling pathways and cell migration in human neutrophils. | Katsube, M., et al. 2008. J Leukoc Biol. 84: 255-63. PMID: 18443189
- SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival. | Tonnetti, L., et al. 2008. Cancer Res. 68: 5648-57. PMID: 18632617
- Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. | Chen, YF., et al. 2011. Proc Natl Acad Sci U S A. 108: 15225-30. PMID: 21876174
- Stimulation of human formyl peptide receptors by calpain inhibitors: homology modeling of receptors and ligand docking simulation. | Fujita, H., et al. 2011. Arch Biochem Biophys. 516: 121-7. PMID: 22005393
- Calcium, calpain, and calcineurin in low-frequency depression of transmitter release. | Silverman-Gavrila, LB., et al. 2013. J Neurosci. 33: 1975-90. PMID: 23365236
- Calpain-dependent regulation of the skeletal muscle atrophy following unloading. | Shenkman, BS., et al. 2015. Arch Biochem Biophys. 584: 36-41. PMID: 26297661
- Revealing the three dimensional architecture of focal adhesion components to explain Ca2+-mediated turnover of focal adhesions. | Chang, SJ., et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 624-635. PMID: 28063985
- The coordinated outcome of STIM1-Orai1 and superoxide signalling is crucial for headkidney macrophage apoptosis and clearance of Mycobacterium fortuitum. | Dahiya, P., et al. 2021. Dev Comp Immunol. 114: 103800. PMID: 32771347
- An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. | Wang, KK., et al. 1996. Proc Natl Acad Sci U S A. 93: 6687-92. PMID: 8692879
- Alpha-mercaptoacrylic acid derivatives as novel selective calpain inhibitors. | Wang, KK., et al. 1996. Adv Exp Med Biol. 389: 95-101. PMID: 8860998
- Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis. | Nath, R., et al. 1996. Neuroreport. 8: 249-55. PMID: 9051790
- Mechanisms of renal tubular cell hypertrophy: mitogen-induced suppression of proteolysis. | Franch, HA., et al. 1997. Am J Physiol. 273: C843-51. PMID: 9316404
- Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. | Debiasi, RL., et al. 1999. J Virol. 73: 695-701. PMID: 9847375
Inhibitor of:
Calpain, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 145305, 5 mg | sc-222131 | 5 mg | $255.00 |