(+)-PD 128907 hydrochloride CAS: 300576-59-4
MF: C14H19NO3•HCl
MW: 285.77
A potent D3DR agonist.

(+)-PD 128907 hydrochloride (CAS 300576-59-4)

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Alternate Names: (4aR,10bR)-3,4a,4,10b-Tetrahydro-4- propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-o l hydrochloride
Application: (+)-PD 128907 hydrochloride is a potent D3DR agonist
CAS Number: 300576-59-4
Purity: ≥98%
Molecular Weight: 285.77
Molecular Formula: C14H19NO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(+)-PD 128907 hydrochloride is a potent D3DR (dopamine receptor) agonist (Ki = 2.3 nM). It displays 18 to 200-fold selectivity over other dopamine receptor subtypes.


References

Pugsley et al (1995) Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J.Pharmacol.Exp.Ther. 275 1355. Bristow et al (1996) The behavioural and neurochemical profile of the putative dopamine D3 receptor agonist, (+)-PD 128907, in the rat. Neuropharmacology 35 285. Witkin et al (1998) Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur.J.Pharmacol. 347 R1.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in ethanol (>10 mg/ml), DMSO (18 mg/ml), and water (9 mg/ml).
Storage :
Desiccate at 4° C
Refractive Index :
n20D ~1.55 (Predicted)
Optical Activity :
α20/D +84.1°, c = 1.07 in water
IC50 :
SR-2A: EC5050 = 21.59 nM (mouse); MOR-1: EC5050 = 92.45 µM (human)
Ki Data :
D dopamine receptor : Ki= 2.3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957668
MDL Number :
MFCD00210210
SMILES :
CCCN1CCO[[email protected]]2[[email protected]]1COC3=C2C=C(C=C3)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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