Molecular structure of Pamidronate, Disodium Salt, CAS Number: 109552-15-0
Pamidronate, Disodium Salt (CAS 109552-15-0)
Application:
Pamidronate, Disodium Salt is a calcium metabolism regulator
CAS Number:
109552-15-0
Purity:
≥95%
Molecular Weight:
369.1
Molecular Formula:
C3H9NO7P2•2Na•5H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pamidronate, Disodium Salt is a bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. In addition, Pamidronate selectively activates γδTcells in peripheral blood mononuclear cells. Alternate studies indicate that Pamidronate, Disodium Salt promotes osteoblast proliferation and differentiation while inhibiting osteoclastogenesis and osteoclast function. Furthermore, Pamidronate down-regulates urokinase-type plasminogen activator expression by suppressing uPA mRNA in PC-3 cells.
Pamidronate, Disodium Salt (CAS 109552-15-0) References
- Gamma/delta T-cell stimulation by pamidronate. | Kunzmann, V., et al. 1999. N Engl J Med. 340: 737-8. PMID: 10068336
- Use of pamidronate disodium to reduce cholecalciferol-induced toxicosis in dogs. | Rumbeiha, WK., et al. 2000. Am J Vet Res. 61: 9-13. PMID: 10630770
- Uses and effectiveness of pamidronate disodium for treatment of dogs and cats with hypercalcemia. | Hostutler, RA., et al. 2005. J Vet Intern Med. 19: 29-33. PMID: 15715044
- Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cells from dogs. | Ashton, JA., et al. 2005. Am J Vet Res. 66: 885-91. PMID: 15934617
- Pamidronate down-regulates urokinase-type plasminogen activator expression in PC-3 prostate cancer cells. | Iguchi, K., et al. 2007. Anticancer Res. 27: 3843-8. PMID: 18225541
- Alendronate and Pamidronate calcium phosphate bone cements: setting properties and in vitro response of osteoblast and osteoclast cells. | Panzavolta, S., et al. 2009. J Inorg Biochem. 103: 101-6. PMID: 18977031
- Pamidronate disodium for palliative therapy of feline bone-invasive tumors. | Wypij, JM. and Heller, DA. 2014. Vet Med Int. 2014: 675172. PMID: 25013741
- Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. | Xu, Y., et al. 2017. J Oral Maxillofac Surg. 75: 2135-2143. PMID: 28412267
- Effects of pamidronate administration on tooth eruption and mandibular growth in new born rats. | Tuncer, I., et al. 2017. J Istanb Univ Fac Dent. 51: 8-14. PMID: 28955580
- 'Turn-Off' Fluorescent Sensor for Pamidronate Disodium and Zoledronic Acid Based on Newly Synthesized Carbon Dots from Black Tea. | Li, P. and Hu, Y. 2018. J Anal Methods Chem. 2018: 3631249. PMID: 29725552
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FDPS.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pamidronate, Disodium Salt, 10 mg | sc-203178 | 10 mg | $78.00 |