Date published: 2026-2-5

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Palmitoyl Ethanolamide-d4 (CAS 1159908-45-8)

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Alternate Names:
PEA-d4
Application:
Palmitoyl Ethanolamide-d4 is a useful deuterium labeled palmitoyl ethanolamide
CAS Number:
1159908-45-8
Molecular Weight:
303.50
Molecular Formula:
C18H33D4NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Palmitoyl Ethanolamide-d4 contains four deuterium atoms at the 7, 7′, 8, and 8′ positions and is intended for use as an internal standard for the quantification of PEA by GC- or LC-mass spectrometry. PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues. Central cannabinoid (CB1) receptors have no appreciable affinity for PEA.3 Palmitoyl Ethanolamide-d4 is an activator of CB2, GPR55, PPAR alpha and CB1. Palmitoyl Ethanolamide-d4 is also a substrate of FAAH.


Palmitoyl Ethanolamide-d4 (CAS 1159908-45-8) References

  1. Psychophysiology and Experimental Psychopathology. A tribute to Samuel Sutton. New York, New York, March 18, 1987.  |  . 1992. Ann N Y Acad Sci. 658: 1-286. PMID: 1353948
  2. FATTY ACID AMIDES OF ETHANOLAMINE IN MAMMALIAN TISSUES.  |  BACHUR, NR., et al. 1965. J Biol Chem. 240: 1019-24. PMID: 14284696
  3. [The state of child health in Trujillo, Peru: survey of morbidity in children under 5 years of age].  |  Rivera Castañeda, C., et al. 1978. Bol Oficina Sanit Panam. 84: 157-71. PMID: 147091
  4. Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans.  |  Harrison, N., et al. 2014. PLoS One. 9: e113007. PMID: 25423491
  5. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.  |  Gouveia-Figueira, S., et al. 2015. PLoS One. 10: e0139212. PMID: 26406890
  6. Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry.  |  Sempio, C., et al. 2021. Anal Bioanal Chem. 413: 3381-3392. PMID: 33817753
  7. Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.  |  Borgmeyer, M., et al. 2021. Cell Rep. 37: 109797. PMID: 34610315
  8. Fatty acid esters as novel metabolites of γ-hydroxybutyric acid: A preliminary investigation.  |  Kraemer, M., et al. 2022. Drug Test Anal. 14: 690-700. PMID: 34983082
  9. Changes in plasma endocannabinoids concentrations correlate with 18F-FDG PET/MR uptake in brown adipocytes in humans.  |  Maliszewska, K., et al. 2023. Front Mol Biosci. 10: 1073683. PMID: 37564131
  10. β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?  |  Klawitter, J., et al. 2024. Mol Pharmacol. 105: 75-83. PMID: 38195158

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Palmitoyl Ethanolamide-d4, 100 µg

sc-224199
100 µg
$29.00

Palmitoyl Ethanolamide-d4, 500 µg

sc-224199A
500 µg
$130.00