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Paclitaxel-d5 (CAS 1129540-33-5)

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Alternate Names:
Abraxane-d5; Genaxol-d5; Genetaxyl-d5
Application:
Paclitaxel-d5 is a deuterium-labeled antineoplastic
CAS Number:
1129540-33-5
Purity:
≥98%
Molecular Weight:
858.94
Molecular Formula:
C47H46D5NO14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Paclitaxel-d5, a deuterium-labeled variant of Paclitaxel, is a compound of significant interest in the realm of chemical and biochemical research. The incorporation of five deuterium atoms, which are heavy isotopes of hydrogen, into the Paclitaxel molecule distinguishes it from its non-labeled counterpart in terms of physical and chemical properties, particularly in the context of its molecular weight and spectroscopic characteristics. This deuterium labeling is for enhancing the accuracy and precision of analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. In these applications, Paclitaxel-d5 can serve as an internal standard, providing a reference for quantification and compound identification. The distinct mass due to the deuterium atoms allows for clear differentiation between the labeled and non-labeled molecules, facilitating more accurate and detailed analysis of chemical compositions and interactions.


Paclitaxel-d5 (CAS 1129540-33-5) References

  1. Paclitaxel in cancer therapy.  |  Mekhail, TM. and Markman, M. 2002. Expert Opin Pharmacother. 3: 755-66. PMID: 12036415
  2. A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease.  |  Stone, GW., et al. 2004. N Engl J Med. 350: 221-31. PMID: 14724301
  3. Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging.  |  Morosi, L., et al. 2013. PLoS One. 8: e72532. PMID: 23991120
  4. A rapid analytical method for the quantification of paclitaxel in rat plasma and brain tissue by high-performance liquid chromatography and tandem mass spectrometry.  |  Li, P., et al. 2013. Rapid Commun Mass Spectrom. 27: 2127-34. PMID: 23996385
  5. Characterization of matrix effects in developing rugged high-throughput LC-MS/MS methods for bioanalysis.  |  Li, F., et al. 2016. Bioanalysis. 8: 1021-34. PMID: 27079811
  6. Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging.  |  Giordano, S., et al. 2016. Sci Rep. 6: 39284. PMID: 28000726
  7. Simultaneous quantification of reparixin and paclitaxel in plasma and urine using ultra performance liquid chromatography-tandem mass spectroscopy (UHPLC-MS/MS): Application to a preclinical pharmacokinetic study in rats.  |  Malhi, S., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1046: 165-171. PMID: 28187377
  8. Analytical and clinical validation of a dried blood spot assay for the determination of paclitaxel using high-performance liquid chromatography-tandem mass spectrometry.  |  Andriguetti, NB., et al. 2018. Clin Biochem. 54: 123-130. PMID: 29514052
  9. Cytochrome P450 enzymes contribute to the metabolism of LSD to nor-LSD and 2-oxo-3-hydroxy-LSD: Implications for clinical LSD use.  |  Luethi, D., et al. 2019. Biochem Pharmacol. 164: 129-138. PMID: 30981875
  10. Novel Drug Delivery Method Targeting Para-Aortic Lymph Nodes by Retrograde Infusion of Paclitaxel into Pigs' Thoracic Duct.  |  Saito, A., et al. 2022. Cancers (Basel). 14: PMID: 35954416
  11. Inhibition of neurite initiation and growth by taxol.  |  Letourneau, PC. and Ressler, AH. 1984. J Cell Biol. 98: 1355-62. PMID: 6143759
  12. Taxol: an antimitotic agent with a new mechanism of action.  |  Manfredi, JJ. and Horwitz, SB. 1984. Pharmacol Ther. 25: 83-125. PMID: 6149569
  13. Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells.  |  Danesi, R., et al. 1995. Mol Pharmacol. 47: 1106-11. PMID: 7603448

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Paclitaxel-d5, 1 mg

sc-219546
1 mg
$568.00

Paclitaxel-d5, 10 mg

sc-219546A
10 mg
$4168.00

Is this item in stock?

Asked by: ssteinmetz
Thank you for your question. Please contact our Customer Care Department to inquire about current product availability. Please call us at (800) 457-3801 option 1, email us at customercare@scbt.com, or contact us by live chat!
Answered by: Technical Support
Date published: 2016-09-28
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Rated 5 out of 5 by from Liu KK; et alLiu KK; et al. (PubMed ID: 20634575) determined that Paclitaxel-d5 covalently linked to nanodiamonds still retains its cytotoxicity to A549 cells. -SCBT Publication Review
Date published: 2015-07-03
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Paclitaxel-d5 is rated 5.0 out of 5 by 1.
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