Oxacillin Sodium Salt Monohydrate (CAS 7240-38-2)

Oxacillin Sodium Salt Monohydrate is a chemically modified form of oxacillin, designed for enhanced solubility and stability in aqueous solutions, making it suitable for experimental use in various scientific studies. It is particularly valuable in the study of bacterial resistance mechanisms and the molecular biology of penicillin-binding proteins (PBPs). The primary mechanism of action of Oxacillin Sodium Salt Monohydrate involves the inhibition of bacterial cell wall synthesis. It achieves this by binding to PBPs located inside the bacterial cell wall. PBPs play a crucial role in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. By binding to these proteins, Oxacillin Sodium Salt Monohydrate disrupts peptidoglycan cross-linking, resulting in a weakened cell wall that cannot withstand osmotic pressure, ultimately leading to cell lysis. In research, this compound has been extensively used to explore the genetics and biochemistry of antibiotic resistance, particularly in methicillin-resistant Staphylococcus aureus (MRSA) strains. Studies involving Oxacillin Sodium Salt Monohydrate help in understanding how bacterial populations evolve under antibiotic pressure, which genes are involved in resistance, and how these genes affect the bacterial cell′s physiology.