OTX3 Antibody (E-9): sc-515294

OTX3 Antibody (E-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects OTX3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OTX3 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OTX3 plays a crucial role in the development of the central nervous system, particularly in the regulation of gene expression during brain development. OTX3 is primarily located in developing neural tissues, where OTX3 is essential for postnatal survival and growth. OTX3 functions as a transcriptional repressor, specifically inhibiting OTX2-mediated transactivation by forming a heterodimer with OTX2 on the TAATCC consensus motif, which is vital for maintaining the balance of gene expression necessary for proper brain patterning and development. The interaction between OTX3 and OTX2 highlights the importance of these proteins in the intricate network of transcription factors that govern neural development, ensuring that the brain develops correctly and functions optimally.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

OTX3 Antibody (E-9) References:

1. Otx genes and the genetic control of brain morphogenesis.  |  Acampora, D., et al. 1999. Mol Cell Neurosci. 13: 1-8. PMID: 10049527
2. Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.  |  Acampora, D., et al. 1999. Development. 126: 1417-26. PMID: 10068635
3. The TINS Lecture. Understanding the roles of Otx1 and Otx2 in the control of brain morphogenesis.  |  Acampora, D. and Simeone, A. 1999. Trends Neurosci. 22: 116-22. PMID: 10199636
4. Otx genes in corticogenesis and brain development.  |  Acampora, D., et al. 1999. Cereb Cortex. 9: 533-42. PMID: 10498271
5. Identification, tissue expression, and functional characterization of Otx3, a novel member of the Otx family.  |  Zhang, Y., et al. 2002. J Biol Chem. 277: 28065-9. PMID: 12055180
6. Neonatal lethality, dwarfism, and abnormal brain development in Dmbx1 mutant mice.  |  Ohtoshi, A. and Behringer, RR. 2004. Mol Cell Biol. 24: 7548-58. PMID: 15314164
7. Functional analysis of transcriptional repressor Otx3/Dmbx1.  |  Kimura, K., et al. 2005. FEBS Lett. 579: 2926-32. PMID: 15890343
8. Chromosome locations of human EMX and OTX genes.  |  Kastury, K., et al. 1994. Genomics. 22: 41-5. PMID: 7959790

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OTX3 Antibody (E-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-OTX3 Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OTX3 Antibody (E-9) Specifications

Alternate Product Name: OTX3

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 123-290

Epitope Target: OTX3

Epitope Species: human

Product Reactivity/Detection: OTX3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for OTX3 Antibody (E-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin