Molecular structure of Orotidine, CAS Number: 314-50-1
Orotidine (CAS 314-50-1)
Alternate Names:
Orotidine is also known as Uridine-6-carboxylic acid.
Application:
Orotidine is a nucleoside found naturally in fungi, bacteria and plants, and used as a reference in the research of disease and metabolic deficiencies.
CAS Number:
314-50-1
Purity:
≥90%
Molecular Weight:
288.21
Molecular Formula:
C10H12N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Orotidine is extensively utilized in biochemical research, particularly for its involvement in pyrimidine biosynthesis. This compound is in studies focusing on the enzymatic pathways responsible for nucleotide synthesis, where it acts as a substrate in the conversion process mediated by orotate phosphoribosyltransferase and orotidine-5′-phosphate decarboxylase. Research with Orotidine often aims to elucidate the mechanisms of these enzymes, providing insights into genetic regulation and metabolic control. Additionally, Orotidine is used in investigations of metabolic disorders related to nucleotide biosynthesis, offering a deeper understanding of disease states at a molecular level. Furthermore, its role in the synthesis and regulation of RNA and DNA is explored, enhancing knowledge of cellular replication and transcription processes.
Orotidine (CAS 314-50-1) References
- The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase. | Begley, TP., et al. 2000. Curr Opin Struct Biol. 10: 711-8. PMID: 11114509
- Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase. | Gao, J. 2003. Curr Opin Struct Biol. 13: 184-92. PMID: 12727511
- Inhibition of orotidine-5'-monophosphate decarboxylase--discoveries and lessons. | Kotra, LP. and Pai, EF. 2008. Nucleic Acids Symp Ser (Oxf). 85-6. PMID: 18776265
- Semi-targeted analysis of metabolites using capillary-flow ion chromatography coupled to high-resolution mass spectrometry. | Burgess, K., et al. 2011. Rapid Commun Mass Spectrom. 25: 3447-52. PMID: 22002700
- Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions. | Amyes, TL., et al. 2012. Biochemistry. 51: 4630-2. PMID: 22620855
- Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. | Purohit, MK., et al. 2012. J Med Chem. 55: 9988-97. PMID: 22991951
- Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates. | Goryanova, B., et al. 2013. Biochemistry. 52: 537-46. PMID: 23276261
- Phylogenetic analysis reveals a cryptic species Blastomyces gilchristii, sp. nov. within the human pathogenic fungus Blastomyces dermatitidis. | Brown, EM., et al. 2013. PLoS One. 8: e59237. PMID: 23533607
- Orotidine Monophosphate Decarboxylase--A Fascinating Workhorse Enzyme with Therapeutic Potential. | Fujihashi, M., et al. 2015. J Genet Genomics. 42: 221-34. PMID: 26059770
- Bifunctional activity of fused Plasmodium falciparum orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase. | Paojinda, P., et al. 2018. Parasitol Int. 67: 79-84. PMID: 28389349
- Orotidine-Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA. | Kim, EK., et al. 2017. Chemistry. 23: 12668-12675. PMID: 28708927
- Enzyme Architecture: Erection of Active Orotidine 5'-Monophosphate Decarboxylase by Substrate-Induced Conformational Changes. | Reyes, AC., et al. 2017. J Am Chem Soc. 139: 16048-16051. PMID: 29058891
- A profound computational study to prioritize the natural compound inhibitors against the P. falciparum orotidine-5-monophosphate decarboxylase enzyme. | Manhas, A., et al. 2020. J Biomol Struct Dyn. 38: 2704-2716. PMID: 31304874
- Disruption or reduced expression of the orotidine-5'-decarboxylase gene pyrG increases citric acid production: a new discovery during recyclable genome editing in Aspergillus niger. | Zhang, L., et al. 2020. Microb Cell Fact. 19: 76. PMID: 32209089
- Orotidine 5'-Monophosphate Decarboxylase: The Operation of Active Site Chains Within and Across Protein Subunits. | Brandão, TAS. and Richard, JP. 2020. Biochemistry. 59: 2032-2040. PMID: 32374983
- Protein-Ribofuranosyl Interactions Activate Orotidine 5'-Monophosphate Decarboxylase for Catalysis. | Cristobal, JR., et al. 2021. Biochemistry. 60: 3362-3373. PMID: 34726391
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Orotidine, 1 mg | sc-222103 | 1 mg | $170.00 | |||
Orotidine, 5 mg | sc-222103A | 5 mg | $675.00 | |||
Orotidine, 10 mg | sc-222103B | 10 mg | $1336.00 | |||
Orotidine, 25 mg | sc-222103C | 25 mg | $2907.00 |