Molecular structure of Okadaic Acid, Ammonium Salt, CAS Number: 155716-06-6
Okadaic Acid, Ammonium Salt (CAS 155716-06-6)
See product citations (10)
Application:
Okadaic Acid, Ammonium Salt is a protein phosphatase regulator with high specificity for PP1, PP2A and polycation-modulated phosphatases.
CAS Number:
155716-06-6
Purity:
≥98%
Molecular Weight:
822.0
Molecular Formula:
C44H67O13•NH4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Okadaic Acid, Ammonium Salt, a toxin originally derived from Halichondria okadai, has been reported to have a relatively high specificity for PP1, PP2A, and polycation-modulated phosphatases. The mechanistic studies show that this is achieved by the compound′s non-competitive or mixed inhibition of the okadaic acid-sensitive enzymes. Additional experiments have noted Okadaic Acid to induce ornithine decarboxylase in mouse skin and be a non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter in murine skin carcinogenesis. Okadaic Acid displays the capacity to inhibit insulin secretion induced by ketoisocaproate, high K+, and Tolbutamide (sc-203298), via suppression of the magnitude of Ca2+ signal in β cells.
Okadaic Acid, Ammonium Salt (CAS 155716-06-6) References
- Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors. | Ludowyke, RI., et al. 1998. Cell Biol Int. 22: 855-65. PMID: 10873297
- Nonradioactive technique to measure protein phosphatase 2A-like activity and its inhibition by drugs in cell extracts. | Fathi, AR., et al. 2002. Anal Biochem. 310: 208-14. PMID: 12423640
- Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice. | Moncada, A., et al. 2003. Eur J Pharmacol. 465: 53-60. PMID: 12650833
- Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics. | Bialojan, C. and Takai, A. 1988. Biochem J. 256: 283-90. PMID: 2851982
- Pulsed light reduces the toxicity of the algal toxin okadaic acid to freshwater crustacean Daphnia pulex. | Murray, IMT., et al. 2018. Environ Sci Pollut Res Int. 25: 607-614. PMID: 29052147
- SUMOylation of periplakin is critical for efficient reorganization of keratin filament network. | Gujrati, M., et al. 2019. Mol Biol Cell. 30: 357-369. PMID: 30516430
- A window into the brain: Tools to assess pre-clinical efficacy of biomaterials-based therapies on central nervous system disorders. | Samal, J., et al. 2019. Adv Drug Deliv Rev. 148: 68-145. PMID: 30710594
- Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter. | Suganuma, M., et al. 1988. Proc Natl Acad Sci U S A. 85: 1768-71. PMID: 3126494
- Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification. | Asghari, P., et al. 2020. Elife. 9: PMID: 31916935
- The Cell Cycle Checkpoint System MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in Anucleate Human Platelets. | Kumm, EJ., et al. 2020. Cells. 9: PMID: 32085646
- Loss of 4E-BP converts cerebellar long-term depression to long-term potentiation. | Saviuk, N., et al. 2022. Cell Rep. 39: 110911. PMID: 35675781
- Stimulation of protein phosphatases as a mechanism of the muscarinic-receptor-mediated inhibition of cardiac L-type Ca2+ channels. | Herzig, S., et al. 1995. Pflugers Arch. 429: 531-8. PMID: 7617443
- Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line. | Gjertsen, BT., et al. 1994. J Cell Sci. 107 (Pt 12): 3363-77. PMID: 7706392
- Dephosphorylation and deactivation of Ca2+/calmodulin-dependent protein kinase II in betaTC3-cells is mediated by Mg2+- and okadaic-acid-sensitive protein phosphatases. | Easom, RA., et al. 1998. Biochem J. 329 (Pt 2): 283-8. PMID: 9425110
- Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion. | Sato, Y., et al. 1998. Br J Pharmacol. 123: 97-105. PMID: 9484859
Inhibitor of:
Apoptosis, PP1, and PP2.Activator of:
PKC ι, and PKC lambda.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Okadaic Acid, Ammonium Salt, 25 µg | sc-202260 | 25 µg | $64.00 |