Molecular structure of Octylonium Bromide, CAS Number: 26095-59-0
Octylonium Bromide (CAS 26095-59-0)
See product citations (3)
Alternate Names:
Otilonium bromide
Application:
Octylonium Bromide is a PAF-R inhibitor
CAS Number:
26095-59-0
Purity:
98%
Molecular Weight:
563.6
Molecular Formula:
C29H43N2O4Br
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Octylonium Bromide has been reported to antagonize PAF (platelet-activating factor) induced aggregation of rabbit platelet-rich plasma, hypotension in rats, lethality in mice, and bronchoconstriction in guinea-pigs. This compound also demonstrates the ability to potently block neuronal nicotinic acetylcholine receptors and also a mild wide-spectrum Ca2+ channel blocker in bovine adrenal chromaffin cells. Additionally, Octylonium Bromide has been shown to inhibit muscular action potentials carried by L-type Ca2+ current. Octylonium Bromide is an inhibitor of PAF-R.
Octylonium Bromide (CAS 26095-59-0) References
- Stability-indicating methods for determining omeprazole and octylonium bromide in the presence of their degradation products. | el-Kousy, NM. and Bebawy, LI. 1999. J AOAC Int. 82: 599-606. PMID: 10367377
- Otilonium bromide: a selective spasmolytic for the gastrointestinal tract. | Evangelista, S. 1999. J Int Med Res. 27: 207-22. PMID: 10689627
- Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon. | Martin, MT., et al. 2004. Neurogastroenterol Motil. 16: 175-83. PMID: 15086871
- Autoradiographic localization of octylonium bromide binding sites in the rat gastrointestinal tract. | Amenta, F., et al. 1991. Arch Int Pharmacodyn Ther. 311: 5-19. PMID: 1724144
- T-type Ca(2+) channel modulation by otilonium bromide. | Strege, PR., et al. 2010. Am J Physiol Gastrointest Liver Physiol. 298: G706-13. PMID: 20203058
- Octylonium bromide interacts competitively with the PAF receptor. | Barone, D., et al. 1989. Drugs Exp Clin Res. 15: 363-7. PMID: 2557193
- Octylonium bromide, an antagonist of platelet-activating factor. | Subissi, A., et al. 1989. Arch Int Pharmacodyn Ther. 302: 255-67. PMID: 2636821
- Effect of cimetropium bromide and other antispasmodic compounds on in vitro guinea-pig gallbladder. | Scarpignato, C., et al. 1989. Methods Find Exp Clin Pharmacol. 11: 323-9. PMID: 2755278
- Otilonium Bromide treatment prevents nitrergic functional and morphological changes caused by chronic stress in the distal colon of a rat IBS model. | Traini, C., et al. 2021. J Cell Mol Med. 25: 6988-7000. PMID: 34109728
- Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters. | Xu, C., et al. 2022. Commun Biol. 5: 613. PMID: 35729200
- System and organ-selectivity of smooth muscle relaxants on in vitro spontaneously contracting preparations. | Manzini, S., et al. 1984. Arch Int Pharmacodyn Ther. 270: 50-60. PMID: 6149732
- Octylonium bromide: a smooth muscle relaxant which interferes with calcium ions mobilization. | Maggi, CA., et al. 1983. Arch Int Pharmacodyn Ther. 264: 305-23. PMID: 6639222
- Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. | Gandía, L., et al. 1996. Br J Pharmacol. 117: 463-470. PMID: 8821535
Inhibitor of:
PAF-R, and SLC7A6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Octylonium Bromide, 5 mg | sc-201035 | 5 mg | $154.00 | |||
Octylonium Bromide, 25 mg | sc-201035A | 25 mg | $583.00 |