Date published: 2025-9-16

1-800-457-3801

SCBT Portrait Logo
Seach Input

Octafluoroacetophenone (CAS 652-22-2)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Perfluoroacetophenone
CAS Number:
652-22-2
Molecular Weight:
264.07
Molecular Formula:
C8F8O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Octafluoroacetophenone, also referred to as perfluoroacetophenone, is a versatile synthetic compound extensively utilized in scientific research and laboratory experiments. This compound is a colorless, odorless, and flammable liquid, belonging to the family of fluorinated hydrocarbons. Octafluoroacetophenone′s unique properties have positioned it as a prominent tool in scientific research. Its broad range of applications encompasses the synthesis of other fluorinated compounds, investigations into enzyme kinetics, and explorations of the interaction between biological molecules and fluorinated surfaces. Furthermore, its contribution to the study of the environmental impact of fluorinated compounds has been noteworthy. Octafluoroacetophenone is generally considered to be non-toxic, non-carcinogenic, and non-irritating to the skin and eyes. It exhibits low acute toxicity and does not possess mutagenic or teratogenic properties. However, its high flammability and potential respiratory irritation upon inhalation require cautious handling. Acting as a fluorinating agent, octafluoroacetophenone adds fluorine atoms to other molecules owing to its electron-withdrawing properties. This mechanism enables the formation of stable compounds and serves as the foundation for its role in synthesizing various fluorinated compounds.


Octafluoroacetophenone (CAS 652-22-2) References

  1. Reaction of difluoromethyl pentafluorophenyl sulfoxide with nucleophiles  |  , et al. (2017). Russian Journal of Organic Chemistry. volume 53,: pages 1012–1016.
  2. Synthesis and properties of new halogen-substituted 2-pentafluorophenyl-2-trifluoromethyl-1,3-dioxolanes  |  , et al. (2009). Russian Journal of Applied Chemistry. volume 82,: pages 2156–2160.
  3. Electronic structure and OK α spectra of carbonyl-containing pentafluorobenzene derivatives  |  , et al. (1993). Russian Chemical Bulletin volume. 42,: pages 270–275.
  4. Aromatic polyfluoro-compounds. Part XXXI. The synthesis and reactions of some halogenomethylpentafluorophenylmethanols and routes to some pentafluorophenylacetylenes  |  P. L. Coe, R. G. Plevey and J. C. Tatlow. 1966,. J. Chem. Soc. C,. Issue 0, 1966: 597-603.
  5. Hydrogen abstraction from aromatic aldehydes by trifluoromethyl radicals  |  J. R. Majer, S-A. M. A. Naman and J. C. Robb. 1969,. Trans. Faraday Soc.,. 65:, 3295-3300.
  6. Aromatic Monocarbonylpolyfluoro-compounds  |  https://iopscience.iop.org/article/10.1070/RC1980v049n06ABEH002488/meta. 1980. Russ. Chem. Rev. 49: 558.
  7. Transition Metal/Base-Catalyzed Aldol Reactions of Isocyanoacetic Acid Derivatives with Prochiral Ketones, a Straightforward Approach to Stereochemically Defined β,β-Disubstituted-β-hydroxy-α-amino Acids.1 Scope and Limitations  |  https://pubs.acs.org/doi/abs/10.1021/jo9623402. 1997,. J. Org. Chem. 62,: 11, 3470–3479.
  8. A new non-metal heterogeneous catalyst for the activation of hydrogen peroxide: a perfluorinated ketone attached to silica for oxidation of aromatic amines and alkenes  |  Karine Neimanna and Ronny Neumann*a. 2001. Chem. Commun.,. Issue 5, 2001:, 487-488.
  9. Dramatic Enhancement of Superacid-Catalyzed Polyhydroxyalkylation Reactions  |  Maria T. Guzmán-Gutiérrez†, Daniel R. Nieto†, Serguei Fomine†, Salvador L. Morales†, Mikhail G. Zolotukhin*†, M. Carmen G. Hernandez‡, Hans Kricheldorf§⊥, and Edward S. Wilks∥. 2011. Macromolecules., 44, 2,: 194–202.
  10. Tuning Aryl−CH···O Intermolecular Interactions on Pt(111)†  |  Vincent Demers-Carpentier, Marc-André Laliberté‡, Yunxiang Pan§, Gautier Mahieu‡, Stéphane Lavoie‡, Guillaume Goubert‡, Bjørk Hammer§, and Peter H. McBreen*‡. 2011,. J. Phys. Chem. C. 115, 4,: 1355–1360.
  11. The Synthesis and Characterization of Highly Fluorinated Aromatic Polyimides  |  CD Simone, E Vaccaro, DA Scola - Journal of Fluorine Chemistry, 2019 - Elsevier. August 2019,. Journal of Fluorine Chemistry,. Volume 224: Pages 100-112.
  12. Transition metal-catalyzed diastereoselective aldol reactions of prochiral ketones with methyl isocyanoacetate  |  VA Soloshonok, AD Kacharov, DV Avilov, T Hayashi -. 21 October 1996,. Tetrahedron Letters. Volume 37, Issue 43,: Pages 7845-7848.
  13. A Novel, One-Pot Synthesis of Novel 3F, 5F, and 8F Aromatic Polymers  |   and Adan M. Diaz, Mikhail G. Zolotukhin, Serguei Fomine, Roberto Salcedo, Octavio Manero, Gerardo Cedillo, Victor M. Velasco, Maria T. Guzman, Detlev Fritsch, Alexei F. Khalizov. January 23, 2007. Macromolecular Rapid Communications. Volume28, Issue2: Pages 183-187.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Octafluoroacetophenone, 1 g

sc-236238
1 g
$209.00