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Obidoxime Chloride (CAS 114-90-9)

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Alternate Names:
1,1′[Oxybis(methylene)]-bis[4-(hydroxyimino)methyl]pyridinium Dichloride; Toxogonin Dichloride; Toxogonine; Toksobidin
Application:
Obidoxime Chloride is a cholinesterase reactivator
CAS Number:
114-90-9
Purity:
98%
Molecular Weight:
359.21
Molecular Formula:
C14H16Cl2N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Obidoxime chloride is primarily utilized in research as an antidote model to study the effects of organophosphate poisoning on enzymes such as acetylcholinesterase (AChE). It acts by reactivating AChE that has been inactivated by organophosphate compounds, which are used in various pesticides and nerve agents. This reactivation is for understanding the biochemical pathways and mechanisms of action that underlie organophosphate toxicity. In biochemical assays, obidoxime chloride serves as a reference compound, allowing researchers to evaluate the efficacy of new reactivators. Moreover, its role in binding studies provides insights into the structural requirements for effective interaction with AChE, facilitating the design of novel compounds with potential applications in mitigating the effects of enzyme inhibition by organophosphates.


Obidoxime Chloride (CAS 114-90-9) References

  1. Autocatalytic degradation and stability of obidoxime.  |  Rubnov, S., et al. 1999. J Pharm Pharmacol. 51: 9-14. PMID: 10197411
  2. The role of oximes in the management of organophosphorus pesticide poisoning.  |  Eyer, P. 2003. Toxicol Rev. 22: 165-90. PMID: 15181665
  3. Simple high-performance liquid chromatographic method for determination of atropine and obidoxime in a parenteral injection device.  |  Gören, AC., et al. 2004. J Chromatogr A. 1057: 237-9. PMID: 15584245
  4. Spectrophotometric determination of obidoxime chloride as its Pd(II) complex in water and injections.  |  Karljiković-Rajić, K., et al. 1987. J Pharm Biomed Anal. 5: 141-9. PMID: 16867534
  5. Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime chloride and trimedoxime.  |  Zhang, YH., et al. 2007. Arch Toxicol. 81: 785-92. PMID: 17534602
  6. A quantitative NMR protocol for the simultaneous analysis of atropine and obidoxime in parenteral injection devices.  |  Sharma, R., et al. 2009. J Pharm Biomed Anal. 49: 1092-6. PMID: 19299099
  7. Development of a combined solution formulation of atropine sulfate and obidoxime chloride for autoinjector and evaluation of its stability.  |  Ettehadi, HA., et al. 2013. Iran J Pharm Res. 12: 31-6. PMID: 24250669
  8. Efficacy of atropine sulfate/obidoxime chloride co-formulation against sarin exposure in guinea pigs.  |  Joosen, MJA., et al. 2018. Chem Biol Interact. 296: 34-42. PMID: 30217478
  9. In vitro evaluation of two different types of obidoxime-loaded nanoparticles for cytotoxicity and blood-brain barrier transport.  |  Sezigen, S., et al. 2020. Toxicol Lett. 330: 53-58. PMID: 32380126
  10. Pharmacokinetics and efficacy of atropine sulfate/obidoxime chloride co-formulation against VX in a guinea pig model.  |  Kentrop, J., et al. 2021. Regul Toxicol Pharmacol. 119: 104823. PMID: 33212192
  11. Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions.  |  Caratsch, CG. and Waser, PG. 1984. Pflugers Arch. 401: 84-90. PMID: 6382149
  12. Determination of atropine and obidoxime in automatic injection devices used as antidotes against nerve agent intoxication.  |  Pohjola, J. and Harpf, M. 1994. J Chromatogr A. 686: 350-4. PMID: 7881533
  13. Carbamate poisoning and oxime treatment in children: a clinical and laboratory study.  |  Lifshitz, M., et al. 1994. Pediatrics. 93: 652-5. PMID: 8134223

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Obidoxime Chloride, 1 g

sc-212467
1 g
$486.00