Molecular structure of O2,2′-Cyclouridine, CAS Number: 3736-77-4
O2,2′-Cyclouridine (CAS 3736-77-4)
Application:
O2,2′-Cyclouridine is a research tool for anticancer and antiviral studies
CAS Number:
3736-77-4
Molecular Weight:
226.19
Molecular Formula:
C9H10N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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O2,2′-Cyclouridine, a naturally occurring organic compound, represents a modified derivative of uracil. Scientific research has harnessed the potential of O2,2′-Cyclouridine across various applications. It has proven valuable as an inhibitor of multiple enzymes, including reverse transcriptase, DNA polymerase, and RNA polymerase. O2,2′-Cyclouridine exerts its inhibitory effects on enzymes by binding to their active sites, thereby impeding substrate binding. O2,2′-Cyclouridine also acts as a substrate in a range of biochemical reactions, facilitating the synthesis of nucleosides and nucleotides.
O2,2′-Cyclouridine (CAS 3736-77-4) References
- Further studies on the photochemistry of pyrimidines, with special reference to 5-and 6-substituted derivatives in relation to photoreactivation in the T-even bacteriophages. | WIERZCHOWSKI, KL. and SHUGAR, D. 1960. Acta Biochim Pol. 7: 63-84. PMID: 13844652
- The biosynthesis of deoxyribonucleic acid by the chick embryo. II. Metabolism of O2:2'-cyclouridine. | REICHARD, P. 1959. J Biol Chem. 234: 2719-22. PMID: 14437042
- Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues. | Brulikova, L. and Hlavac, J. 2011. Beilstein J Org Chem. 7: 678-98. PMID: 21804865
- Optical rotatory studies on nucleic acid derivatives. Eta-pi transitions and the relation of the B 2u cotton effect to conformation in pyrimidine and azapyrimidine nucleosides. | Rogers, GT. and Ulbricht, TL. 1971. Eur J Biochem. 22: 457-66. PMID: 5171543
- Arabinonucleotides. I. A study of the formation of 3,-arabinonucleotidyl esters by the conversion of an internucleotide linkage. | Nagyvary, J. and Provenzale, RG. 1969. Biochemistry. 8: 4769-75. PMID: 5370009
- Synthesis and structure of polyarabinouridylic acid. | Provenzale, RG. and Nagyvary, J. 1970. Biochemistry. 9: 1744-52. PMID: 5439035
- Magnetic circular dichroism and circular dichroism of some nucleosides. | Hatano, M., et al. 1980. Nucleic Acids Symp Ser. s125-8. PMID: 7255183
- The crystal and molecular structure of O2, 2'-cyclouridine. Influence of O (2)–C (2') cyclization on the sugar conformation of pyrimidine nucleosides. | Suck, D. I. E. T. R. I. C. H. and W. O. L. F. R. A. M. Saenger. 1973. Acta Crystallographica Section B: Structural Crystallography and Crystal Chemistry. 29.6: 1323-1330.
- Synthesis of 6, 6'-Cyclo-5', 6'-dideoxy-1-(β-D-allofuranosyl) cytosine and Related Nucleosides: Nucleosides and Nucleotides. LXXXVIII. | YOSHIMURA, Yuichi, et al. 1989. Chemical and pharmaceutical bulletin. 37.3: 660-664.
- Reactions Of 2′-Deoxy-2′-halouridines and O 2, 2′-Cyclouridine with Lithium Dialkylamides: Formation of 1′, 2′-Unsaturated Derivatives. | Kittaka, Atsushi, et al. 1992. Nucleosides & nucleotides. 11.1: 37-47.
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UPase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O2,2′-Cyclouridine, 1 g | sc-257938 | 1 g | $132.00 |