Molecular structure of NVP-231, CAS Number: 362003-83-6
NVP-231 (CAS 362003-83-6)
Alternate Names:
adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide; N-[2-(benzoylamino)-6-benzothiazolyl]-Tricyclo[3.3.1.13,7]decane-1-carboxamide
Application:
NVP-231 is a newly discovered potent, specific and reversible CerK inhibitor
CAS Number:
362003-83-6
Molecular Weight:
431.55
Molecular Formula:
C25H25N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
NVP-231 is a newly discovered potent, specific and reversible CerK inhibitor that competitively inhibits binding of ceraminde to CerK. Ceramide kinase presents an attractive target for drug development because of its involvement in cell growth and inflammation. CerK biology is still poorly understood thus discovery and availability of inhibitors will facilitate research at this area.
NVP-231 (CAS 362003-83-6) References
- Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor. | Graf, C., et al. 2008. Mol Pharmacol. 74: 925-32. PMID: 18612076
- A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides. | Graf, C., et al. 2009. Anal Biochem. 384: 166-9. PMID: 18831956
- Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro. | Niwa, S., et al. 2009. Microvasc Res. 77: 389-93. PMID: 19323974
- Ceramide kinase contributes to proliferation but not to prostaglandin E2 formation in renal mesangial cells and fibroblasts. | Pastukhov, O., et al. 2014. Cell Physiol Biochem. 34: 119-33. PMID: 24977486
- The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death. | Pastukhov, O., et al. 2014. Br J Pharmacol. 171: 5829-44. PMID: 25134723
- Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells. | Rivera, IG., et al. 2016. Biochem Pharmacol. 102: 107-119. PMID: 26707801
- Ceramide-1-phosphate protection of cochlear hair cells against cisplatin ototoxicity. | Le, Q., et al. 2016. Toxicol Rep. 3: 450-457. PMID: 28959567
- Ceramide Kinase Is Upregulated in Metastatic Breast Cancer Cells and Contributes to Migration and Invasion by Activation of PI 3-Kinase and Akt. | Schwalm, S., et al. 2020. Int J Mol Sci. 21: PMID: 32092937
- Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells. | Al-Rashed, F., et al. 2021. Sci Rep. 11: 8259. PMID: 33859296
- Ceramide Kinase Inhibition Blocks IGF-1-Mediated Survival of Otic Neurosensory Progenitors by Impairing AKT Phosphorylation. | León, Y., et al. 2021. Front Cell Dev Biol. 9: 678760. PMID: 34179008
- Ceramide-1-Phosphate Is Involved in Therapy-Induced Senescence. | Millner, A., et al. 2022. ACS Chem Biol. 17: 822-828. PMID: 35353506
- Decreased Innate Migration of Pro-Inflammatory M1 Macrophages through the Mesothelial Membrane Is Affected by Ceramide Kinase and Ceramide 1-P. | Ku, CW., et al. 2022. Int J Mol Sci. 23: PMID: 36555618
- Inhibition of Ceramide Kinase Is Effective against Cisplatin-Resistant Ovarian Cancer Cells by Regulating Ceramide and C1P Levels. | Zou, J. and Jian, L. 2023. Gynecol Obstet Invest. 88: 61-70. PMID: 36682357
Inhibitor of:
Ceramide Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NVP-231, 5 mg | sc-255397 | 5 mg | $115.00 |