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Nortriptyline Hydrochloride (CAS 894-71-3)

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Alternate Names:
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine Hydrochloride; Acetexa; Allegron
Application:
Nortriptyline Hydrochloride is a 5-HT2 serotonin receptor antagonist
CAS Number:
894-71-3
Molecular Weight:
299.84
Molecular Formula:
C19H21N•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nortriptyline Hydrochloride is a compound that is studied within the realms of neurology and biochemistry for its impact on neurotransmitter dynamics. It is primarily used in research models to examine its effects on the reuptake of norepinephrine and serotonin, two key neurotransmitters in the central nervous system. The compound serves as useful for scientists looking to understand the modulation of monoaminergic systems and the resulting biochemical responses. Investigations utilizing Nortriptyline Hydrochloride also delve into its influence on various receptors and ion channels, which contributes to the broader comprehension of neuronal communication and regulation. Additionally, research on this compound encompasses studies on its kinetics and metabolic pathways in order to elucidate the compound′s distribution, metabolism, and elimination in biological systems.


Nortriptyline Hydrochloride (CAS 894-71-3) References

  1. Comparison of UV spectrophotometric and LC methods for the determination of nortriptyline hydrochloride in polysorbate 80 based oil/water (o/w) microemulsions.  |  Moreno, ., et al. 2000. J Pharm Biomed Anal. 22: 287-94. PMID: 10719911
  2. Release of nortriptyline hydrochloride from oil-water microemulsions.  |  Moreno, M., et al. 2000. Chem Pharm Bull (Tokyo). 48: 1623-7. PMID: 11086887
  3. Stability indicating method for determination of nortriptyline hydrochloride using 3-methyl-2-benzothiazolinone hydrazone (MBTH).  |  El Ragehy, NA., et al. 2001. J Pharm Biomed Anal. 25: 143-51. PMID: 11274868
  4. Sensitive extractive spectrophotometric methods for the determination of nortriptyline hydrochloride in pharmaceutical formulations.  |  Misiuk, W. and Tykocka, A. 2007. Chem Pharm Bull (Tokyo). 55: 1655-61. PMID: 18057736
  5. Nortriptyline hydrochloride skin absorption: development of a transdermal patch.  |  Melero, A., et al. 2008. Eur J Pharm Biopharm. 69: 588-96. PMID: 18191555
  6. Enhancement of nortriptyline penetration through human epidermis: influence of chemical enhancers and iontophoresis.  |  Merino, V., et al. 2008. J Pharm Pharmacol. 60: 415-20. PMID: 18380912
  7. Second-derivative synchronous fluorescence spectroscopy for the simultaneous determination of fluphenazine hydrochloride and nortriptyline hydrochloride in pharmaceutical preparations.  |  Walash, MI., et al. 2009. J Fluoresc. 19: 891-904. PMID: 19418209
  8. Nortriptyline for smoking cessation: release and human skin diffusion from patches.  |  Melero, A., et al. 2009. Int J Pharm. 378: 101-7. PMID: 19501148
  9. Wistar rat skin as surrogate for human skin in nortriptyline hydrochloride patch studies.  |  Melero, A., et al. 2010. Int J Pharm. 384: 137-9. PMID: 19781607
  10. A structural powder diffraction study of two polymorphic forms of nortriptyline hydrochloride.  |  Vladiskovic, C., et al. 2012. J Pharm Sci. 101: 4481-9. PMID: 22987224
  11. Kinetic modelling for the assay of nortriptyline hydrochloride using potassium permanganate as oxidant.  |  Rahman, N. and Khan, S. 2015. AAPS PharmSciTech. 16: 569-78. PMID: 25380790
  12. Nortriptyline Hydrochloride Solubility-pH Profiles in a Saline Phosphate Buffer: Drug-Phosphate Complexes and Multiple pHmax Domains with a Gibbs Phase Rule 'Soft' Constraints.  |  Marković, OS., et al. 2022. Mol Pharm. 19: 710-719. PMID: 35050628
  13. Nortriptyline in depressed patients with left ventricular impairment.  |  Roose, SP., et al. 1986. JAMA. 256: 3253-7. PMID: 3783871

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nortriptyline Hydrochloride, 10 mg

sc-212422
10 mg
$250.00

Nortriptyline Hydrochloride, 100 mg

sc-212422A
100 mg
$224.00

Nortriptyline Hydrochloride, 1 g

sc-212422B
1 g
$469.00