Date published: 2025-10-20

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Nornidulin (CAS 33403-37-1)

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Alternate Names:
2,4,7-trichloro-3,8-dihydroxy-1,9-dimethyl-6-(1-methyl-1-propen-1-yl)-11H-dibenzo[b,e][1,4]dioxepin-11-one
Application:
Nornidulin is a potent, selective antibacterial agent
CAS Number:
33403-37-1
Purity:
>99%
Molecular Weight:
429.7
Molecular Formula:
C19H15Cl3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Nornidulin is a naturally occurring fungal metabolite classified as a mycotoxin, produced primarily by certain species of Aspergillus and Penicillium. It is structurally related to other compounds in the xanthocillin class and exhibits intriguing biological activities, particularly its ability to inhibit bacterial and fungal growth, which makes it a point of interest in microbial ecology and natural product chemistry research. The mechanism through which nornidulin acts involves the disruption of essential cellular processes in microorganisms, such as protein synthesis and enzyme activity, which can lead to the inhibition of microbial proliferation. In research contexts, nornidulin has been employed to study its biosynthetic pathways within producing fungi, offering insights into the genetics and enzymatic processes involved in mycotoxin production. This research is critical for understanding how fungi compete with other microorganisms in their natural environments, contributing to broader ecological studies. Additionally, nornidulin has served as a model compound in the exploration of natural product-derived bioactive substances, aiding in the identification of potential new leads for the development of biocontrol agents that could manage the growth of harmful bacteria and fungi in various environmental and industrial settings.


Nornidulin (CAS 33403-37-1) References

  1. Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03.  |  Sureram, S., et al. 2012. Planta Med. 78: 582-8. PMID: 22307935
  2. Expanding antibiotic chemical space around the nidulin pharmacophore.  |  Morshed, MT., et al. 2018. Org Biomol Chem. 16: 3038-3051. PMID: 29634062
  3. Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant.  |  Yang, WC., et al. 2018. Molecules. 23: PMID: 30177651
  4. Semisynthesis and antibacterial activities of nidulin derivatives.  |  Isaka, M., et al. 2019. J Antibiot (Tokyo). 72: 181-184. PMID: 30555155
  5. Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored.  |  Domingos, LTS., et al. 2022. Biomolecules. 12: PMID: 36551248
  6. Nornidulin, A New Inhibitor of Plasmodium falciparum Malate: Quinone Oxidoreductase (PfMQO) from Indonesian Aspergillus sp. BioMCC f.T.8501.  |  Cahyono, AW., et al. 2023. Pharmaceuticals (Basel). 16: PMID: 37259413
  7. Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly.  |  Yang, J., et al. 2023. Acta Pharm Sin B. 13: 3919-3929. PMID: 37719379
  8. Discovery of Fungus-Derived Nornidulin as a Novel TMEM16A Inhibitor: A Potential Therapy to Inhibit Mucus Secretion in Asthma.  |  Pongkorpsakol, P., et al. 2023. J Exp Pharmacol. 15: 449-466. PMID: 38026233
  9. Fungal Depsidones Stimulate AKT-Dependent Glucose Uptake in 3T3-L1 Adipocytes.  |  Chantarasakha, K., et al. 2024. J Nat Prod.. PMID: 38597733

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Nornidulin, 1 mg

sc-202252
1 mg
$236.00