Molecular structure of nor-Binaltorphimine dihydrochloride, CAS Number: 105618-26-6
nor-Binaltorphimine dihydrochloride (CAS 105618-26-6)
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Alternate Names:
nor-BNI dihydrochloride
Application:
nor-Binaltorphimine dihydrochloride is a selective KOR antagonist
CAS Number:
105618-26-6
Purity:
≥96%
Molecular Weight:
734.71
Molecular Formula:
C40H43N3O6•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
nor-Binaltorphimine dihydrochloride is a highly selective KOR (kappa-opioid receptor) antagonist in neurobiological studies. Aiding in the understanding of the kappa opioid receptor′s involvement in the modulation of neurotransmitters and neural pathways. By blocking this receptor, researchers can observe changes in biological responses, helping to elucidate the receptor′s contribution to physiological processes. Additionally, this compound is widely used in receptor binding assays to characterize the interaction between kappa opioid receptors and potential ligands, thus serving as a tool in receptor pharmacology research.
nor-Binaltorphimine dihydrochloride (CAS 105618-26-6) References
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- Kappa opioid receptors mediate where fear is expressed following extinction training. | Cole, S., et al. 2011. Learn Mem. 18: 88-95. PMID: 21245209
- Local kappa opioid receptor activation decreases temporomandibular joint inflammation. | Chicre-Alcântara, TC., et al. 2012. Inflammation. 35: 371-6. PMID: 21484425
- Perivascular expression and potent vasoconstrictor effect of dynorphin A in cerebral arteries. | Ruisanchez, É., et al. 2012. PLoS One. 7: e37798. PMID: 22662226
- Centrally administered apelin-13 induces depression-like behavior in mice. | Lv, SY., et al. 2012. Brain Res Bull. 88: 574-80. PMID: 22728209
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- The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. | Yeganeh-Hajahmadi, M., et al. 2017. Hypertens Res. 40: 732-737. PMID: 28275232
- Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension. | Rostamzadeh, F., et al. 2018. Clin Exp Pharmacol Physiol. 45: 187-197. PMID: 28945940
- Spexin/NPQ Induces FBJ Osteosarcoma Oncogene (Fos) and Produces Antinociceptive Effect against Inflammatory Pain in the Mouse Model. | Lv, SY., et al. 2019. Am J Pathol. 189: 886-899. PMID: 30664863
- Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. | Telpoukhovskaia, MA., et al. 2020. Sci Rep. 10: 13688. PMID: 32792571
- Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch. | Sakai, K., et al. 2020. J Neurosci. 40: 7688-7701. PMID: 32895292
- The Opioid Interactions of the Antipsychotic Medications Risperidone and Amisulpride in Mice and Their Potential Use in the Treatment of Other Non-Psychotic Medical Conditions. | Schreiber, S. and Pick, CG. 2021. Cell Mol Neurobiol. 41: 1077-1084. PMID: 33184770
- 100 Hz Electroacupuncture Alleviated Chronic Itch and GRPR Expression Through Activation of Kappa Opioid Receptors in Spinal Dorsal Horn. | Li, HP., et al. 2021. Front Neurosci. 15: 625471. PMID: 33664646
- Blockade of the antinociceptive activity of centrally administered ketorolac by nor-binaltorphimine. | Tripathi, A. and Welch, SP. 1995. Eur J Pharmacol. 278: 27-32. PMID: 7664811
- Antinociceptive activity of intrathecal ketorolac is blocked by the kappa-opioid receptor antagonist, nor-binaltorphimine. | Uphouse, LA., et al. 1993. Eur J Pharmacol. 242: 53-8. PMID: 8223936
Inhibitor of:
KOR, and KOR-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nor-Binaltorphimine dihydrochloride, 1 mg | sc-396970A | 1 mg | $48.00 | |||
nor-Binaltorphimine dihydrochloride, 10 mg | sc-396970 | 10 mg | $186.00 |