NOR-5
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NOR-5, known as 5-nitro-2-furaldehyde, is a chemical compound that functions as a nitrofuran derivative. It acts as a potent antibacterial agent by inhibiting bacterial growth through interference with the synthesis of bacterial DNA and RNA. NOR-5 exerts its mode of action by forming covalent bonds with bacterial proteins, leading to disruption of cellular processes. NOR-5 targets the bacterial cell wall and membrane, causing structural damage and compromising the integrity of the bacterial cell. NOR-5 generates reactive oxygen species within the bacterial cell, resulting in oxidative stress and ultimately leading to bacterial cell death. Its mechanism of action involves the generation of DNA-damaging free radicals, which contribute to the bactericidal activity of NOR-5. NOR-5 plays a role in experimental applications by serving as a potent antibacterial agent with a specific mode of action that targets bacterial cellular processes.
NOR-5 References
- Therapy of peritoneally disseminated colon cancer by TAP-deficient embryonic stem cell-derived macrophages in allogeneic recipients. | Haga, E., et al. 2014. J Immunol. 193: 2024-33. PMID: 25031460
- Relaxant and antioxidant capacity of the red wine polyphenols, resveratrol and quercetin, on isolated mice corpora cavernosa. | Boydens, C., et al. 2015. J Sex Med. 12: 303-12. PMID: 25443137
- Nitric oxide enhanced the growth of an obligated intracellular bacterium Orientia tsutsugamushi in murine macrophages. | Ogawa, M., et al. 2017. Microb Pathog. 107: 335-340. PMID: 28412201
- Nitric oxide represses the proliferation of Caco-2 cells by inducing S-G2/M cell cycle arrest. | Sakuma, S., et al. 2019. Int J Physiol Pathophysiol Pharmacol. 11: 205-211. PMID: 31777644
- Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases. | Macháček, T., et al. 2020. Parasit Vectors. 13: 426. PMID: 32819437
- Fe(II) and Pyridinic N complex sites synergy to activate PMS for specific generation of 1O2 to degrade antibiotics with high efficiency. | Zhang, X., et al. 2023. Sci Total Environ. 164067. PMID: 37257621
- Oral biological activities of spontaneous nitric oxide releasers are accounted for by their nitric oxide-releasing rates and oral absorption manners. | Kita, Y., et al. 1996. J Pharmacol Exp Ther. 276: 421-5. PMID: 8632305
- Comparison of hemodynamic effects of nitric oxide (NO) donors with different NO-releasing properties in rats. | Kita, Y., et al. 1997. J Cardiovasc Pharmacol. 30: 223-8. PMID: 9269950
- Comparison of antiplatelet effects of two nitric oxide-donating agents, FR146801 and FK409. | Hirasawa, Y., et al. 1998. Thromb Haemost. 79: 620-4. PMID: 9531052
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOR-5, 5 mg | sc-222076 | 5 mg | $131.00 | |||
NOR-5, 10 mg | sc-222076A | 10 mg | $227.00 |